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M-cadherin and its sisters in development of striated muscle

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Cadherins are calcium-dependent, transmembrane intercellular adhesion proteins with morphoregulatory functions in the development and maintenance of tissues. In the development of striated muscle, the expression and function of mainly M-, N-, and R-cadherin has been studied so far. While these three cadherins are expressed in skeletal muscle cells, of these only N-cadherin is expressed in cardiac muscle. In this review, M-, N-, and R-cadherin are discussed as important players in the terminal differentiation and possibly also in the commitment of skeletal muscle cells. Furthermore, reports are described which evaluate the essential role of N-cadherin in the formation of heart tissue.

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Received: 3 September 1998 / Accepted: 25 November 1998

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Kaufmann, U., Martin, B., Link, D. et al. M-cadherin and its sisters in development of striated muscle. Cell Tissue Res 296, 191–198 (1999). https://doi.org/10.1007/s004410051280

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  • Key words M-
  • N-
  • and R-cadherin
  • Catenins
  • Microtubules
  • Microfilaments