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Cell and Tissue Research

, Volume 377, Issue 3, pp 469–474 | Cite as

Immune activity at the gut epithelium in the larval sea urchin

  • Katherine M. BuckleyEmail author
  • Jonathan P. RastEmail author
Mini Review

Abstract

The embryo of the purple sea urchin has been a fruitful model for the study of developmental gene regulatory networks. For similar reasons, the feeding sea urchin larva provides a gene regulatory model to investigate immune interactions at the gut epithelium. Here we describe what is known of the gut structure and immune cells of the sea urchin larva, and the cellular and gene expression response of the larva to gut-associated immune challenge. As a focused example of how the sea urchin larva can be compared with vertebrate systems, we discuss the expression and function of the IL-17 signalling system in the course of the larval immune response.

Keywords

Mucosal immunity IL-17 Inflammation Vibrio Barrier immunity 

Notes

Funding information

JPR is supported by a grant from the Natural Sciences and Engineering Research Council (RGPIN-2017-06247).

Compliance with ethical standards

Conflict of interest

The authors declare that there is no conflict of interest.

Ethical approval

This article does not contain any studies with animals performed by any of the authors.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Biological SciencesAuburn UniversityAuburnUSA
  2. 2.Emory University School of Medicine, Pathology & Laboratory MedicineAtlantaUSA

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