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Cell and Tissue Research

, Volume 377, Issue 1, pp 95–106 | Cite as

Neurogenesis and antidepressant action

  • Seon-Cheol ParkEmail author
Review

Abstract

A theoretical framework is proposed to gain insight into the pathogenesis of major depressive disorder (MDD). Despite being a relatively weak argument, the neurogenesis theory is suggested to compensate for the limitations of the monoamine theory. In the adult hippocampus, neurogenesis is functionally related to regulation of the hypothalamic–pituitary–adrenal (HPA) axis, inflammatory processes, cognitive functions and other aspects that contribute to etiological factors that lead to MDD and promote recovery from MDD. Despite a lack of investigation into neurogenesis and antidepressant action, it is proposed that chronic administration of antidepressant(s) can induce the recruitment and integration of newborn neurons into the dentate gyrus and, ultimately, lead to the remission of MDD. The extant body of literature indicates that the suppression of neurogenesis per se may be associated with an impaired response to antidepressant treatment rather than with the induction of depressive-like behaviors. Moreover, recent studies have shown that increasing the survival rate and incorporation of new neurons can alleviate depressive-like behaviors and promote stress resilience. According to the neurogenic reserve hypothesis, hippocampal neurogenesis supports specific cortical functions, including executive functions, pattern separation and contextual information processing, control over the HPA axis and behavioral coping mechanisms in response to stressful situations. Therefore, hippocampal neurogenesis may be a promising biological indicator of stress resilience and antidepressant response in patients with MDD.

Keywords

Antidepressant Biological indicator Hippocampus Major depressive disorder (MDD) Neurogenesis 

Notes

References

  1. Alenina N, Klempin F (2015) The role of serotonin in adult hippocampal neurogenesis. Behav Brain Res 277:49–57Google Scholar
  2. Alonso R, Griebel G, Pavone G, Semmelin J, Le Fur G, Soubrie P (2004) Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression. Mol Psychiatry 9:278–286Google Scholar
  3. Anacker C, Luna VM, Stevens GS, Millette A, Shores R, Jimenez JC, Chen B, Hen R (2018) Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus. Nature 559:98–102Google Scholar
  4. Appel JR, Ye S, Tang F, Sun D, Zhang H, Mei L, Xiong WC (2018) Increased microglial activity, impaired adult hippocampal neurogenesis, and depressive-like behavior in microglial VPS35-depleted mice. J Neurosci 38:5949–5968Google Scholar
  5. Apple DM, Fonseca RN, Kokovay E (2017) The role of adult neurogenesis in psychiatric and cognitive disorders. Brain Res 1655:270–276Google Scholar
  6. Banasr M, Hery M, Printemps R, Daszuta A (2004) Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentated gyrus and the subventricular zone. Neuropsychopharmacology 29:450–460Google Scholar
  7. Bannerman DM, Deacon RMJ, Offen S, Friswell J, Grub M, Rawlins JNP (2002) Double dissociation of function within the hippocampus: spatial memory and hyponeophagia. Behav Neurosci 116:884–901Google Scholar
  8. Baptista P, Andrade JP (2018) Adult hippocampal neurogenesis: regulation and possible correlates. Front Neuroanat 12:44Google Scholar
  9. Beason-Held LL, Rosene DL, Killiany RJ, Moss MB (1999) Hippocampal formation lesions produce memory impairment in the rhesus monkey. Hippocampus 9:562–574Google Scholar
  10. Bennet AJ, Lesch KP, Heils A, Long JC, Lorenz JC, Lorenz JG, Shoaf SE (2002) Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry 7:118–122Google Scholar
  11. Bergmann O, Liebl J, Bernard S, Alkass K, Yeung MS, Steier P, Kutschera W, Johnson L, Landén M, Druid H, Spalding KL, Frisén J (2012) The age of olfactory bulb neurons in humans. Neuron 74:634–639Google Scholar
  12. Bizon JL, Lee HJ, Gallagher M (2004) Neurogenesis in a rat model of age-related cognitive decline. Aging Cell 3:227–234Google Scholar
  13. Blanchard DC, Canteras NS, Markham CM, Pentkowski NS, Blanchard RJ (2005) Lesions of structures showing FOS expression to cat presentation: effects on responsivity to a cat, cat odor, and nonpredator threat. Neurosci Biobehav Rev 29:1243–1253Google Scholar
  14. Boku S, Nakagawa S, Toda H, Hishimoto A (2017) Neural basis of major depressive disorder: beyond monoamine hypothesis. Psychiatry Clin Neurosci 2018 72:3–12Google Scholar
  15. Boldrini M, Fulmore CA, Tartt AN, Simeon LR, Pavlova I, Poposka V, Rosoklija GB, Stankov A, Arango V, Dwork AJ, Hen R, Mann JJ (2018) Human hippocampal neurogenesis persists throughout aging. Cell Stem Cell 22:589–599Google Scholar
  16. Bremner JD, Vermetten E (2004) Neuroanatomical changes associated with pharmacotherapy in posttraumatic stress disorder. Ann N Y Acad Sci 1032:154–157Google Scholar
  17. Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, Charney DS (2000) Hippocampal volume reduction in major depression. Am J Psychiatry 157:115–118Google Scholar
  18. Bremner JD, Vythilingam M, Vermetten E, Vaccarino V, Charney DS (2004) Deficits in hippocampal and anterior cingulate functioning during verbal declarative memory encoding in midlife major depression. Am J Psychiatry 161:637–645Google Scholar
  19. Brezun JM, Daszuta A (2000) Serotonin may stimulate granule cell proliferation in the adult hippocampus, as observed in rats grafted with foetal raphe neurons. Eur J Neurosci 12:391–399Google Scholar
  20. Brooke SM, de Haas-Johnson AM, Kaplan JR, Manuck SB, Sapolsky RM (1994) Dexamethasone resistance among nonhuman primates associated with a selective decrease of glucocorticoid receptors in the hippocampus and a history of social instability. Neuroendocrinology 60:134–140Google Scholar
  21. Cameron HA, McKay RD (1999) Restoring production of hippocampal neurons in old age. Nat Neurosci 2:894–897Google Scholar
  22. Cameron HA, Tanapat P, Gould E (1998) Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway. Neuroscience 82:349–354Google Scholar
  23. Charvet CJ, Finlay BL (2018) Comparing adult hippocampal neurogenesis across species: translating time to predict the tempo in humans. Front Neurosci 12:706Google Scholar
  24. Clewell T (2004) Mourning beyond melancholia: Freud's psychoanalysis of loss. J Am Psychoanal Assoc 52:43–67Google Scholar
  25. Coe CL, Kramer M, Czeh B, Gould E, Reeves AJ, Kirschbaum C, Fuchs E (2003) Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys. Biol Psychiatry 54:1025–1034Google Scholar
  26. Conrad CD (2010) A critical review of chronic stress effects on spatial learning memory. Prog Neuro-Psychopharmacol Biol Psychiatry 34:742–755Google Scholar
  27. Craft LL, Perna FM (2004) The benefits of exercise for the clinically depressed. Prim Care Companion J Clin Psychiatry 6:104–111Google Scholar
  28. Culig L, Surget A, Bourdey M, Khemissi W, Le Guisquet AM, Vogel E, Sahay A, Hen R, Belzung C (2017) Increasing adult hippocampal neurogenesis in mice after exposure to unpredictable chronic mild stress may counteract some of effects of stress. Neuropharmacology 126:179–189Google Scholar
  29. Czeh B, Lucassen PJ (2007) What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated? Eur Arch Psychiatry Clin Neurosci 257:250–260Google Scholar
  30. Czeh B, Michaelis T, Watanabe T, Frahm J, de Biurrun G, van Kampen M, Bartolomucci A, Fuchs E (2001) Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci U S A 98:12796–12801Google Scholar
  31. Czeh B, Muller-Keuker JL, Rygula R, Abumaria N, Hiemke C, Domenici E (2007) Chronic social stress inhibits cell proliferation in the adult medical prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment. Neuropsychopharmacology 32:1490–1503Google Scholar
  32. David DJ, Klemenhagen KC, Holick KA, Saxe MD, Mendez I, Santarelli L, Craig DA, Zhong H, Swanson CJ, Hedge LG, Ping XI, Dong D, Marzabadi MR, Gerald CP, Hen R (2007) Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methlypropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. J Pharmacol Exp Ther 321:237–248Google Scholar
  33. Degroot A, Treit D (2004) Anxiety is functionally segregated within the septo-hippocampal system. Brain Res 1001:60–71Google Scholar
  34. Deng W, Saxe MD, Gallina IS, Gage FH (2009) Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain. J Neurosci 29:13532–13542Google Scholar
  35. Deuschle M, Kniest A, Neiman H, Erb-Bies M, Colla N, Hamann B, Heuser I (2004) Impaired declarative memory in depressed patients is slow to recover: clinical experience. Pharmacopsychiatry 37:147–151Google Scholar
  36. Dinoff A, Hermann N, Swardfager W, Gallagher D, Lanctot KL (2018) The effect of exercise on resting concentrations of peripheral brain-derived neurotrophic factor (BDNF) in major depressive disorder: a meta-analysis. J Psychiatr Res 105:123–131Google Scholar
  37. Dunkin JJ, Leuchter AF, Cook IA, Kasl-Godley JE, Abrams M, Rosenberg-Thompson S (2000) Executive dysfunction predicts nonresponse to fluoxetine in major depression. J Affect Disord 6:13–23Google Scholar
  38. Dupret D, Revest JM, Koehl M, Ichas F, de Giorgi F, Coster P, Abrous DN, Piazza PV (2009) Spatial relational memory requires hippocampal adult neurogenesis. PLoS One 3:e1959Google Scholar
  39. Eisch AJ, Barrot M, Schad CA, Self DW, Nestler EJ (2000) Opiates inhibit neurogenesis in the adult hippocampus. Proc Natl Acd Sci U S A 97:7579–7584Google Scholar
  40. Eliwa H, Belzung C, Surget A (2017) Adult hippocampal neurogenesis: is it the alpha and omega of antidepressant action? Biochem Pharmacol 141:86–99Google Scholar
  41. Eriksson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, Kim JS, Heo S, Alves H, White SM, Wojcicki TR, Mailey E, Vieira VJ, Martin SA, Pence BD, Woods JA, McAuley E, Kramer AF (2011) Exercise training increase size of hippocampus and improves memory. Proc Natl Acd Sci U S A 108:3017–3022Google Scholar
  42. Eriksson PS, Perfilieva E, Björk-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH (1998) Neurogenesis in the adult human hippocampus. Nat Med 4:1313–1317Google Scholar
  43. Ernst A, Frisen J (2015) Adult neurogenesis in humans—common and unique traits in mammals. PLoS Biol 13:e1002045Google Scholar
  44. Ernst A, Alkass K, Bernard S, Salehpour M, Perl S, Tisdale J, Possnert G, Druid H, Frisén J (2014) Neurogenesis in the striatum of the adult human brains. Cell 156:1072–1083Google Scholar
  45. Esposito MS, Piatti VC, Laplagne DA, Morgenstern NA, Ferrari CC, , Pitossi FJ, Schinder AF (2005) Neuronal differentiation in the adult hippocampus recapitulates embryonic development. J Neurosci 25: 10074–10086Google Scholar
  46. Fang J, Demic S, Cheng S (2018) The reduction of adult neurogenesis in depression impairs the retrieval of new as well as remote episodic memory. PLoS One 13: e0198406Google Scholar
  47. Farioli-Vecchioli S, Saraulli D, Costanzi M, Pacioni S, Cina I, Aceti M, Micheli L, Bacci A, Cestari V, Tirone F (2008) The timing of differentiation of adult hippocampal neurons is crucial for spatial memory. PLoS Biol 6:e246Google Scholar
  48. Frodl T, Schaub A, Banac S, CHarypar M, Jager M, Kummler P, Bottlender R, Zetzsche T, Born C, Leinsinger G, Reiser M, Moller HJ, Meisenzahl (2006) Reduced hippocampal volume correlates with executive dysfunctioning in major depression. J Psychiatry Neurosci 31:316–323Google Scholar
  49. Frodl T, Jäger M, Smajstrlova I, Born C, Bottlender R, Palladino T, Reiser M, Möller HJ, Meisenzahl EM (2008) Effect of hippocampal and amygdala volumes of clinical outcomes in major depression: a 3-year prospective magnetic resonance imaging study. J Psychiatry Neurosci 33:423–430Google Scholar
  50. Godsil BP, Kiss JP, Spedding M, Jay TM (2013) The hippocampal-prefrontal pathway: the weak link in psychiatric disorders? Eur Neuropsychopharmacol 23:1165–1181Google Scholar
  51. Guan Z, Fang J (2006) Peripheral immune activation by lipopolysaccharide decreases neutrophins in the cortex and hippocampus in rats. Brain Behav Immun 20:64–71Google Scholar
  52. Hattiangady B, Rao MS, Shetty GA, Shetty AK (2005) Brain-derived neurotrophic factor, phosphorylated cyclic AMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus. Exp Neurol 195:353–371Google Scholar
  53. Heo EH, Choi KS, Yu JC, Nam JA (2018) Validation of the center for epidemiological studies depression scale among Korean adolescents. Psychiatry Investig 15:124–132Google Scholar
  54. Holsboer F (2000) The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23:477–501Google Scholar
  55. Huckleberry KA, Shue F, Copeland T, Chitwood RA, Yin W, Drew MR (2018) Dorsal and ventral hippocampal adult-born neurons contribute to context fear memory. Neuropsychopharmacology 43:2487–2496Google Scholar
  56. Hunsaker MR, Kesner RP (2008) Dissociations across the dorsal-ventral axis of CA3 and CA1 for encoding and retrieval of contextual and auditory-cued fear. Neurobiol Learn Mem 89:61–69Google Scholar
  57. Insel TR (2012) Next-generation treatments for mental disorders. Sci Transl Med 4:155psc19Google Scholar
  58. Jessberger S, Kempermann G (2003) Adult-born hippocampal neurons mature into activity-dependent responsiveness. Eur J Neurosci 18:2707–2712Google Scholar
  59. Jiang W, Zhang Y, Xiao L, van Cleemput J, Ji S-P, Bai G, Zhang X (2005) Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. J Clin Invest 115:3104–3116Google Scholar
  60. Johansen-Berg H, Gutman DA, Berhrens TE, Matthews PM, Rushworth MF, Katz E, Lozano AM, Mayberg HS (2008) Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression. Cereb Cortex 18:1374–1383Google Scholar
  61. Kang HJ, Kim JW, Kim SY, Kim SW, Shin HY, Shin MG, Kim JM (2018) The MAKE Biomarker discovery for Enhancing anTidepressant Treatment Effect and Response (MAKE BETTER) study: design and methodology. Psychiatry Investig 15:538–545Google Scholar
  62. Karel MJ (1997) Aging and depression: vulnerability and stress across adulthood. Clin Psychol Rev 17:847–879Google Scholar
  63. Kaufman J, Yang BZ, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, Krystal JH, Gelernter J (2006) Brain-derived neurotrophic factor-5HTTLPR gene interactions and environmental modifiers of depression in children. Biol Psychiatry 59:673–680Google Scholar
  64. Kee N, Teixeira CM, Wang AH, Frankland PW (2007) Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nat Neurosci 10:355–362Google Scholar
  65. Kemoun G, Thibaud M, Roumagne N, Carette P, Albinet C, Toussaint L, Paccalin M, Dugué B (2010) Effects of a physical training programme on cognitive function and walking efficiency in elderly persons with dementia. Dement Geriatr Cogn Disord 29:109–114Google Scholar
  66. Kempermann G (2008) The neurogenic reserve hypothesis: what is adult hippocampal neurogenesis good for? Trends Neurosci 31:163–169Google Scholar
  67. Kempermann G, Song H, Gage FH (2015) Neurogenesis in the adult hippocampus. Cold Spring Harb Perspect Biol 7:a018812Google Scholar
  68. Khawaja X, Xu J, Liang JJ, Barrett JE (2004) Proteomic analysis of protein changes developing in rat hippocampus after chronic antidepressant treatment: implications for depressive disorders and future therapies. J Neurosci Res 75:451–460Google Scholar
  69. Khemissi W, Faroog RK, Le Guisquet AM, Sakly M, Belzung C (2014) Dysregulation of the hypothalamus-pituitary-adrenal axis predicts some aspects of the behavioral response to chronic fluoxetine: association with hippocampal cell proliferation. Front Behav Neurosci 8:340Google Scholar
  70. Kirby ED, Friedman AR, Covarrubias D, Ying C, Sun WG, Goosens KA, Sapolsky RM, Kaufer D (2012) Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons. Mol Psychiatry 17:527–536Google Scholar
  71. Klempin F, Babu H, de Pietri Tonelli D, Alarcon E, Fabel K, Kempermann G (2010) Oppositional effects of serotonin receptors 5-HT1a, 2, and 2c in the regulation of adult hippocampal neurogenesis. Front Mol Neurosci 3:1–11Google Scholar
  72. Kodama M, Fujioka T, Duman RS (2004) Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry 56:570–580Google Scholar
  73. Kulkarni VA, Jha S, Vaidya VA (2002) Depletion of nerepinephrine decreases the proliferation but does not influence the survival and differentiation of granule cell progenitors in the adult rat hippocampus. Eur J Neurosci 16:2008–2012Google Scholar
  74. Laroche S, Davis S, Jay TM (2000) Plasticity at hippocampal to prefrontal cortex synapses: dual roles in working memory and consolidation. Hippocampus 10:438–446Google Scholar
  75. Leuner B, Kozorovitskiy Y, Gross CG, Gould E (2007) Diminished adult neurogenesis in the marmoset brain precedes old age. Proc Natl Acad Sci U S A 104:17169–17173Google Scholar
  76. Leutgeb JK, Leutgeb S, Moser MB, Moser EI (2007) Pattern separation in the dentate gyrus and CA3 of the hippocampus. Science 33:2961–2972Google Scholar
  77. Li HY, Zhao YH, Zeng MJ, Fang F, Li M, Qin TT, Ye LY, Li HW, Qu R, Ma SP (2017) Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis. Psychopharmacology 234:3385–3394Google Scholar
  78. Li YF, Zhang YZ, Liu YQ, Wang HL, Yuan L, Luo ZP (2004) Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice. Acta Pharmacol Sin 25:1408–1412Google Scholar
  79. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJL (2006) Global burden of disease and risk factors. World Bank, WashingtonGoogle Scholar
  80. Lucassen PJ, Stumpel MW, Wang Q, Aronica E (2010) Decreased number of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients. Neuropharmacology 58:940–949Google Scholar
  81. Madsen TM, Kristjansen PE, Bolwig TG, Wortwein G (2003) Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in adult rat. Neuroscience 119:635–642Google Scholar
  82. Magnusson JP, Göritz C, Tatarishvili J, Dias DO, Smith EM, Lindvall O, Kokaia Z, Frisén J (2014) A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse. Science 346:237–241Google Scholar
  83. Mahar I, Bambico FR, Mechawar N, Nobrega JN (2014) Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neurosci Biobehav 38:173–192Google Scholar
  84. Malberg JE, Blendy JA (2005) Antidepressant action: to the nucleus and beyond. Trends Pharmacol Sci 26:631–638Google Scholar
  85. Malberg JE, Eisch AJ, Nestler EJ, Duman RS (2000) Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 20:9104–9110Google Scholar
  86. Manganas LN, Zhang X, Li Y, Hazel RD, Smith SD, Wagshul MF, Henn F, Benveniste H, Djuric PM, Enikolopov G, Maletic-Savatic M (2007) Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science 318:980–985Google Scholar
  87. Manji HK, Moore GJ, Chen G (2000) Clinical and preclinical experience for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manic-depressive illness. Biol Psychiatry 48:740–754Google Scholar
  88. Maren S, Holt WG (2004) Hippocampus and Pavlovian fear conditioning in rats: muscimol infusions into the ventral, but not dorsal, hippocampus impair the acquisition of conditional freezing to an auditory conditional stimulus. Behav Neurosci 118:97–110Google Scholar
  89. McEwen BS (2002) Sex, stress and the hippocampus: allostasis, allostatic load and the aging process. Neurobiol Aging 23:921–939Google Scholar
  90. McEwen BS, Chattarji S (2004) Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine. Eur Neuropsychopharmacol 5(Suppl:S497–S502Google Scholar
  91. McGrath PJ, Khan AY, Trivedi MH, Stewart JW, Morris DW, Wisniewski SR, Miyahara S, Nierenberg AA, Fava M, Rush AJ (2008) Response to a selective serotonin reuptake inhibitor (citalopram) in major depressive disorder with melancholic features: a STAR*D report. J Clin Psychiatry 69:1847–1855Google Scholar
  92. Meshi D, Drew MR, Saxe M, Ansorge MS, David D, Santarelli L, Malapani C, Moore H, Hen R (2006) Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment. Nat Neurosci 9:729–731Google Scholar
  93. Micheli L, Ceccarelli M, D'Andrea G, Tirone (2018) Depression and adult neurogenesis: positive effects of the antidepressant fluoxetine and of physical exercise. Brain Res Bull 143:181–193Google Scholar
  94. Miyake A, Friedman NP, Emerson MJ, Witzki AH, Howerter A, Wager TD (2000) The unity and diversity for behavioral effects of environmental enrichment. Nat Neurosci 9:729–731Google Scholar
  95. Monje ML, Toda H, Palmer TD (2003) Inflammatory blockade restores adult hippocampal neurogenesis. Science 302:1760–1765Google Scholar
  96. Newton SS, Collier EF, Hunsberger J, Adams D, Terwilliger R, Selvanayagam E, Duman RS (2003) Gene profile of electroconvulsive seizures: induction of neurotrophic and angiogenic factors. J Neurosci 23:10841–10851Google Scholar
  97. Nixon K, Crews FT (2004) Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcohol. J Neurosci 24:9714–9722Google Scholar
  98. Nollet M, Gaillard P, Tanti A, Girault V, Belzung C, Leman S (2012) Neurogenesis-independent antidepressant-like effects on behavior and stress axis response of a dual orexin receptor antagonis in a rodent model of depression. Neuropsychopharmacology 37:2210–2221Google Scholar
  99. O'Leary OF, Cryan JF (2014) A ventral view on antidepressant action: roles for adult hippocampal neurogenesis along the dorsoventral axis. Trends Pharmacol Sci 35:675–687Google Scholar
  100. Olypher AV, Klement D, Fenton AA (2006) Cognitive disorganization in hippocampus: a physiological model of the disorganization in psychosis. J Neurosci 26:158–168Google Scholar
  101. Overstreet-Wadiche LS, Westbrook GL (2006) Functional maturation of adult-generated granule cells. Hippocampus 16:208–215Google Scholar
  102. Park SC, Shinfuku N, Maramis MM, Lee MS, Park YC (2015) Adjunctive antipsychotic prescriptions for patients with depressive disorders in Asia: the Research on Asian Psychotropic Prescription Patterns for Antidepressant (REAP-AD) study. Am J Psychiatry 172:684–685Google Scholar
  103. Park SJ, Hong S, Jang H, Jang JW, Yuk B, Kim CE, Park S (2018) The prevalence of chronic physical diseases comorbid with depression among different sex and age groups in South Korea: a population-based study, 2007-2014. Psychiatry Investig 15:370–375Google Scholar
  104. Perera TD, Coplan JD, Lisanby SH, Lipira CM, Arif M, Carpio C, Spitzer G, Santarelli L, Scharf B, Hen R, Rosoklija G, Sackeim HA, Dwork AJ (2007) Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates. J Neurosci 27:4894–4901Google Scholar
  105. Perera TD, Park S, Nemirovskaya Y (2008) Cognitive role of neurogenesis in depression and antidepressant treatment. Neuroscientist 124:326–338Google Scholar
  106. Perera TD, Lu D, Thirumangalakudi L, Smith EL, Yaretskiy A, Rosenblum LA, Kral JG, Coplan JD (2011) Correlations between hippocampal neurogenesis and metabolic indices in adult nonhuman primates. Neural Plasticity 2011:1–6Google Scholar
  107. Pham K, Nacher J, Hof PR, McEwen BS (2003) Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus. Eur J Neurosci 17:879–886Google Scholar
  108. van Praag H, Shuber T, Zhao C, Gage FH (2005) Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 25:8680–8685Google Scholar
  109. Raber J, Rola R, LeFevour A, Morhardt D, Curley J, Mizumatsu S, VandenBerq SR, Fike JR (2004) Radiation-induced cognitive impairments are associated changes in indicators of hippocampal neurogenesis. Radiat Res 162:39–47Google Scholar
  110. Rantamäki T (2017) BDNF receptor TrkB as a target of antidepressant. In: Kim Y-K (ed) Major depressive disorder: risk factors, characteristics and treatment options. Nova Science Publisher, New York, pp 277–294Google Scholar
  111. Reif A, Fritzen S, Finger M, Strobel A, Lauer M, Schmitt A, Lesch KP (2006) Neural stem cell proliferation is decreased in schizophrenia, but not in depression. Mol Psychiatry 11:514–522Google Scholar
  112. Sairanen M, Lucas G, Ernfos P, Castren M, Casten E (2005) Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus. J Neurosci 25:1089–1094Google Scholar
  113. Samuels BA, Mendez-David I, Faye C, David SA, Pierz KA, Gardier AM, Hen R, David DJ (2016) Serotonin 1A and serotonin 4 receptors: essential mediators of the neurogenic and behavioral actions of antidepressants. Neuroscientist 22:26–45Google Scholar
  114. Sanai N, Tramontin AD, Quiñones-Hinojosa A, Barbaro NM, Gupta N, Kunwar S, Lawton MT, McDermott MW, Parsa AT, Manuel-García Verdugo J, Berger MS, Alvarez-Buylla A (2004) Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature 427:740–744Google Scholar
  115. Sanai N, Nguyen T, Ihrie RA, Mirzadeh Z, Tsai HH, Wong M, Gupta N, Berger MS, Huang E, Garcia-Verdugo JM, Rowitch DH, Alvarez-Buylla A (2011) Corridors of migrating neurons in the human brain and their decline during infancy. Nature 478:382–286Google Scholar
  116. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805–809Google Scholar
  117. Saravia F, Revsin Y, Lux-Lantos V, Beauquis J, Homo-Delarche F, De Nicola AF (2004) Oestradiol restores cell proliferation in dentate gyrus and subventricular zone of streptozotocin-diabetic mice. J Neuroendocrinol 16:704–710Google Scholar
  118. Saxe MD, Battaglia F, Wang JW, Malleret G, David DJ, Monckton JF, Garcia AD, Sofroniew MW, Kandel ER, Santarelli L, Hen R, Drew MR (2006) Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc Natl Acad Sci U S A 103:17501–17506Google Scholar
  119. Schmidt HD, Duman RS (2007) The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol 18:391–418Google Scholar
  120. Schuch FB, Vancampfort D, Richards J, Rosenbaum S, Ward FB, Stubbs B (2016) Exercise as a treatment for depression: a meta-analysis adjusting for publication bias. J Psychiatr Res 77:42–51Google Scholar
  121. Segman RH, Shapira B, Gorfine M, Lerer B (1995) Onset and time course of antidepressant action: psychopharmacological implications of a controlled trial of electroconvulsive therapy. Psychopharmacology 119:440–448Google Scholar
  122. Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW (1996) Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci U S A 93:3908–3913Google Scholar
  123. Sheline YI, Gado MH, Kraemer HC (2003) Untreated depression and hippocampal volume loss. Am J Psychiatry 160:1516–1518Google Scholar
  124. Shors TJ, Miesegaes G, Beylin A, Zhao M, Rydel T, Gould E (2001) Neurogenesis in the adults is involved in the formation of trace memories. Nature 410:372–376Google Scholar
  125. Shors TJ, Mathew J, Sisti HM, Edgecomb C, Beckoff S, Dalla C (2007) Neurogenesis and helplessness are mediated by controllability in males but not in females. Biol Psychiatry 62:487–495Google Scholar
  126. Snyder JS, Hong NS, McDonald RJ, Wojtowicz JM (2005) A role for adult neurogenesis in spatial long-term memory. Neuroscience 130:843–852Google Scholar
  127. Snyder JS, Soumier A, Brewer M, Pickel K, Cameron HA (2011) Adult hippocampal neurons are more numerous, faster maturing, and more involved in behavior in rats than in mice. J Neurosci 29:14484–14495Google Scholar
  128. Souery D, Oswald P, Massat I, Bailer U, Bollen J, Demyttenaere K, Kasper S, Lecrubier Y, Montgomery S, Serretti A, Zohar J, Mendlewicz J, Group for the Study of Resistant D (2007) Clinical factors associated with treatment resistance in major depressive disorder: results from a European multicenter study. J Clin Psychiatry 68:1062–1070Google Scholar
  129. Spalding KL, Bergmann O, Alkass K, Bernard S, Salehpour M, Huttner HB, Boström E, Westerlund I, Vial C, Buchholz BA, Possnert G, Mash DC, Druid H, Frisén J (2013) Dynamics of hippocampal neurogenesis in adult humans. Cell 153:1219–1227Google Scholar
  130. Stockmeier CA, Mahajan GJ, Konick LC, Overholser JC, Jurjus GJ, Meltzer HY, Uylings HB, Friedman L, Rajkowska G (2004) Cellular changes in the postmortem hippocampus in major depression. Biol Psychiatry 56:640–650Google Scholar
  131. Surget A, Saxe M, Leman S, Ibarguen-Vargas Y, Chalon S, Griebel G, Hen R, Belzung C (2008) Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal. Biol Psychiatry 64:293–301Google Scholar
  132. Tang MM, Lin WJ, Pan YQ, Guan XT, Li YC (2016) Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression. Physiol Behav 2016 161:166–173Google Scholar
  133. Tanti A, Belzung C (2013) Hippocampal neurogenesis: a biomarker for depression or antidepressant effect? Methodological considerations and perspective for future research. Cell Tissue Res 354:203–219Google Scholar
  134. Tashiro A, Makino H, Gage FH (2007) Experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage. J Neurosci 27:3252–3259Google Scholar
  135. Trivedi MA, Coover GD (2004) Lesions of the ventral hippocampus, but not the dorsal hippocampus, impair conditioned fear expression and inhibitory avoidance on the elevated T-maze. Neurobiol Learn Mem 81:172–184Google Scholar
  136. Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ (2006) Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neuroci 9:519–525Google Scholar
  137. Videbech P, Ravnkilde B (2004) Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry 161:1957–1966Google Scholar
  138. Vollmayr B, Simonis C, Weber S, Gass P, Henn F (2003) Reduced cell proliferation in the dentate gyrus is not correlated with the development of learned helplessness. Biol Psychiatry 54:1045–1040Google Scholar
  139. Vythilingam M, Heim C, Newport J, Miller AH, Anderson E, Bronen R, Brummer M, Staib L, Vermetten E, Charney DS, Nemeroff CB, Bremner JD (2002) Childhood trauma associated with smaller hippocampal volume in women with major depression. Am J Psychiatry 159:2072–2080Google Scholar
  140. Wang JW, David DJ, Monckton JE, Battaglia F, Hen R (2008) Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci 28:1374–1384Google Scholar
  141. Winocur G, Wojtowicz JM, Sekeres M, Snyder JS, Wang S (2006) Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus 16:296–304Google Scholar
  142. Yoshimizu T, Chaki S (2004) Increased cell proliferationn in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist. MGS0039. Biochem Biophys Res Commun 315:493–496Google Scholar
  143. Zhang C, McNeil E, Dressler L, Siman R (2007) Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease. Exp Neurol 204:77–87Google Scholar
  144. Zhao C, Deng W, Gage FH (2008) Mechanisms and functional implications of adult neurogenesis. Cell 132:1374–1384Google Scholar

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© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of PsychiatryInje University Haeundae Paik HospitalHaeundae-guRepublic of Korea

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