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Circadian neurogenetics of mood disorders

  • Jorge MendozaEmail author
  • Guillaume Vanotti
Review

Abstract

Mood state alterations are often accompanied by disruptions of daily rhythms of physiology. Circadian rhythms of physiology are controlled by a central clock harbored in the suprachiasmatic nucleus (SCN), which is functionally dependent on the rhythmic expression of several clock genes. The molecular clockwork has been identified in other extra-SCN brain regions, some of which are implicated in the regulation of motivational and emotional states, although their specific circadian role is not fully known. In mood disorders, alterations of the molecular clock have been reported. Thus, functional expression of circadian genes in the brain is compromised in mood diseases. In the present review, we describe the current evidence that implicates the clock gene alterations as an important factor in the development of mood-related disorders. Furthermore, we describe the possible role of other brain clocks, beyond the SCN, in the circadian control of mood. The comprehension of the circadian neural and genetic mechanisms underlying mood alterations might guide towards the identification of optimal drug and non-drug therapies for the cure of depression and other mood disorders.

Keywords

Circadian Clock genes Depression Mood Suprachiasmatic nucleus Habenula 

Notes

Acknowledgments

We thank Dr. Ipek Yalcin for the invitation to contribute to the special issue and Dr. Tando Maduna and Dr. Cristina Sandu for comments on the manuscript.

Funding information

Funding sources are provided by the Agence National de la Recherche (ANR-14-CE13-0002-01 ADDiCLOCK JCJC), the Centre National de la Recherche Scientifique and the Institut Danone France-Fondation pour la Recherche Médicale Consortium.

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© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Institute of Cellular and Integrative NeurosciencesCNRS UPR-3212 University of StrasbourgStrasbourgFrance

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