Isolated aggregates of lymphoid cells in the inner bronchial wall in asthma patients
Here, we report findings in volunteers with bronchial asthma. Biopsies were obtained from the inner bronchial wall before and a short time again after segmental allergen provocation. In most of the baseline biopsies and in all evaluable biopsies after segmental allergen provocation, the follicular lymphoid tissue was detected by immunohistochemistry in the epithelium of these asthmatic patients. The basic occurrence of the tertiary lymphoid tissue in the bronchial mucosa of mild asthmatics was unexpected and may have consequences for the interpretation of pathophysiology, e.g., as a cause or consequence of bronchial asthma.
KeywordsBronchial asthma BALT Isolated aggregated lymphoid cells Tertiary lymphoid tissue Autoimmunity
The skillful technical assistance of the staff members during the study conduct and sample preparation is gratefully acknowledged.
JH and AB conducted the study, JH did the bronchoscopies, FP and SR did the analyses and evaluations, and TT and RP wrote the manuscript.
This work was partly funded by grants from the DFG (SFB587, GRK 1441) and the German Center for Lung Research.
- Huh JC, Strickland DH, Jahnsen FL, Turner DJ, Thomas JA, Napoli S, Tobagus I, Stumbles PA, Sly PD, Holt PG (2003) Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma. J Exp Med 198:19–30CrossRefGoogle Scholar
- Pabst R, Brandzaeg P (2013) Overview of the mucosal immune system structure. In: Principles of mucosal immunology. In: Smith PD, Mac Donald TT, Blumberg RS (eds) . Garland Science, New York, pp 1–18Google Scholar