Neuropeptidergic modulation of GnRH neuronal activity and GnRH secretion controlling reproduction: insights from recent mouse studies

  • Daniel J. Spergel


Gonadotropin-releasing hormone (GnRH) secretion from GnRH neurons and its modulation by neuropeptides are essential for mammalian reproduction. Here, I review the neuropeptides that have been shown to act directly and that may also act indirectly, on GnRH neurons, the reproduction-related processes with which the neuropeptides may be associated or the physiological information they may convey, as well as their cognate receptors, signaling pathways and roles in the modulation of GnRH neuronal firing, [Ca2+]i, GnRH secretion and reproduction. The review focuses on recent research in mice, which offer the most tractable experimental system for studying mammalian GnRH neurons.


GnRH neuron Neuropeptide Receptor Signaling Reproduction 



This article is dedicated to the memory of Prof. Peter H. Seeburg (1944–2016).



Compliance with ethical standards

Conflict of interest

The author declares that he has no conflict of interest.

Supplementary material

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ESM 1 (DTD 42 kb)


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© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurosurgeryYale University School of MedicineNew HavenUSA

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