Abstract
Successful placentation depends on the proper invasion of extravillous trophoblast (EVT) cells into maternal tissues. Previous reports have demonstrated that FoxM1 is oncogenic and plays important roles in angiogenesis, invasion, and metastasis. However, little is known about the roles of FoxM1 in the invasion of EVT cells. EGF, as a growth factor (epidermal growth factor), has been studied extensively in reproduction. JAR cells are a reliable model for studying early invasive trophoblast regulation. We have observed the relationship between EGF and FoxM1 in JAR cells by using specific inhibitors for the intervention in and study of potential signal pathways. We have also tested the ability of JAR cells to be influenced by the expression of FoxM1. Our data indicate that EGF promotes FoxM1 expression through the ERK signal pathway. Over-FoxM1 expression upregulates the ability of JAR cells to migrate and invade and vice versa. Our investigation of FoxM1 should provide new insights into the molecular mechanisms of EVT invasion.
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05 April 2024
A Correction to this paper has been published: https://doi.org/10.1007/s00441-024-03889-4
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This work was supported by National Natural 467 Scientific Grants (no. 30970646), China and the Liaoning Province Natural Science Foundation of China (2014023055).
The original online version of this article was revised: The authors regret that the original version of this paper unfortunately contained an incorrect image in Figure 2C. Those are due to improperly image selection. The correct and incorrect Figure 2C are provided in the erratum article.
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Xie, Y., Cui, D., Sui, L. et al. Induction of forkhead box M1 (FoxM1) by EGF through ERK signaling pathway promotes trophoblast cell invasion. Cell Tissue Res 362, 421–430 (2015). https://doi.org/10.1007/s00441-015-2211-y
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DOI: https://doi.org/10.1007/s00441-015-2211-y