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The laser lesion of the mouse visual cortex as a model to study neural extracellular matrix remodeling during degeneration, regeneration and plasticity of the CNS

Abstract

CNS lesions generally result in impaired function because regeneration of the adult CNS of mammals is poor. A variety of lesion models has been described that serve to further the understanding of the pathophysiology of the damaged tissue. A central cause of aborted regeneration is the glial scar that expresses a plethora of extracellular matrix molecules. Some of these are considered inhibitors of axon growth and regeneration. The laser lesion of the cortex offers the advantage that a circumscribed lesion of defined energy can be delivered to the cortex non-invasively through the intact dura mater and a thinly drilled wet translucent remnant of the skull. Previously, we have shown that distinct ECM is up-regulated in the penumbra of laser lesions in the rat visual cortex. We propose to transfer this model to the mouse, in view of the availability of a large number of genetical models in this small rodent. Here, we discuss this model and the lesion-related ECM that forms the focus of our analysis.

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Acknowledgements

We gratefully acknowledge grant support by the German Research Foundation (DFG, SFB 509, SPP-1172, GRK-736), the Federal Ministry of Education and Research (BMBF), the Land NRW (Stem Cell Network NRW, International Graduate School of Neuroscience IGSN), the Ruhr-University Bochum (Rectorate programs) and the Mercator Foundation.

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Correspondence to Andreas Faissner.

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Roll, L., Mittmann, T., Eysel, U.T. et al. The laser lesion of the mouse visual cortex as a model to study neural extracellular matrix remodeling during degeneration, regeneration and plasticity of the CNS. Cell Tissue Res 349, 133–145 (2012). https://doi.org/10.1007/s00441-011-1313-4

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Keywords

  • Neural stem cells
  • Tenascin
  • Phosphacan/DSD-1-PG
  • Chondroitin sulfate proteoglycans
  • Stem cell niche