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High-mobility group box 1 (HMGB1) as a master regulator of innate immunity

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Abstract

Damage-associated molecular patterns (DAMPs) comprise intracellular molecules characterized by the ability to reach the extracellular environment, where they prompt inflammation and tissue repair. The high-mobility box group 1 (HMGB1) protein is a prototypic DAMP and is highly conserved in evolution. HMGB1 is released upon cell and tissue necrosis and is actively produced by immune cells. Evidence suggests that HMGB1 acts as a key molecule of innate immunity, downstream of persistent tissue injury, orchestrating inflammation, stem cell recruitment/activation, and eventual tissue remodeling.

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Acknowledgements

The work in the authors’ laboratories is supported by the Ministero della Salute, by the AIRC (Associazione Italiana per la Ricerca sul Cancro) and by the MIUR.

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Correspondence to Angelo A. Manfredi.

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Castiglioni, A., Canti, V., Rovere-Querini, P. et al. High-mobility group box 1 (HMGB1) as a master regulator of innate immunity. Cell Tissue Res 343, 189–199 (2011). https://doi.org/10.1007/s00441-010-1033-1

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Keywords

  • High-mobility group box 1 (HMGB1)
  • Innate immunity
  • Damage-associated molecular patterns (DAMPs)