Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

P57 (KIP2) polymorphisms and breast cancer risk


A previous report in this journal has suggested that germline deletions in the proline-alanine-rich (PAPA-repeat) region of P57 (KIP2) are associated with increased risk of a variety of cancers, including breast cancer. We have analyzed the association of P57 PAPA-repeat deletion polymorphisms and breast cancer risk as part of a population-based case-control study of breast cancer. We have not observed an association between the presence of one or two copies of deletion polymorphisms in P57 and breast cancer risk (adjusted odds ratio: 1.1, 95% confidence interval: 0.6–2.0). Further investigation is necessary to determine the functional significance of P57 deletion polymorphisms and their potential relationship with disease.

This is a preview of subscription content, log in to check access.

Author information

Additional information

Received: 9 September 1998 / Accepted: 26 October 1998

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Li, Y., Millikan, R., Newman, B. et al. P57 (KIP2) polymorphisms and breast cancer risk. Hum Genet 104, 83–88 (1999).

Download citation


  • Breast Cancer
  • Confidence Interval
  • Cancer Risk
  • Breast Cancer Risk
  • Adjusted Odds Ratio