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Precise localization of the human gene encoding cell adhesion kinase β (CAKβ/PYK2) to chromosome 8 at p21.1 by fluorescence in situ hybridization

Abstract

Cell adhesion kinase β (CAKβ) is the second protein-tyrosine kinase of the focal adhesion kinase subfamily with large N- and C-domains in addition to the central kinase domain. The cDNA of the human CAKβ has been cloned and used as a probe for the assignment of this gene by fluorescence in situ hybridization. CAKβ is sublocalized on chromosome 8p21.1, a locus frequently involved in allelic losses in colorectal cancers and prostate carcinomas.

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Received: 14 February 1996 / Revised: 29 April 1996

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Inazawa, J., Sasaki, H., Nagura, K. et al. Precise localization of the human gene encoding cell adhesion kinase β (CAKβ/PYK2) to chromosome 8 at p21.1 by fluorescence in situ hybridization. Hum Genet 98, 508–510 (1996). https://doi.org/10.1007/s004390050249

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Keywords

  • Carcinoma
  • Colorectal Cancer
  • Cell Adhesion
  • Focal Adhesion Kinase
  • Human Gene