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Autophagy in aging and longevity

Abstract

Our understanding of the process of autophagy and its role in health and diseases has grown remarkably in the last two decades. Early work established autophagy as a general bulk recycling process which involves the sequestration and transport of intracellular material to the lysosome for degradation. Currently, autophagy is viewed as a nexus of metabolic and proteostatic signalling that can determine key physiological decisions from cell fate to organismal lifespan. Here, we review the latest literature on the role of autophagy and lysosomes in stress response and longevity. We highlight the connections between autophagy and metabolic processes, the network associated with its regulation, and the links between autophagic dysfunction, neurodegenerative diseases, and aging.

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Fig. 1

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Acknowledgements

L.R.L is funded by a grant from the NIH/NIA (R01 AG051810) and a Glenn Award for Research in Biological Mechanisms of Aging from the Glenn Foundation for Medical Research.

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Wong, S.Q., Kumar, A.V., Mills, J. et al. Autophagy in aging and longevity. Hum Genet 139, 277–290 (2020). https://doi.org/10.1007/s00439-019-02031-7

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