The relevance of loci associated with blood lipids recently identified in European populations in individuals of African ancestry is unknown. We tested association between lipid traits and 36 previously described single-nucleotide polymorphisms (SNPs) in 1,466 individuals of African ancestry from Spanish Town, Jamaica. For the same allele and effect direction as observed in individuals of European ancestry, SNPs at three loci (1p13, 2p21, and 19p13) showed statistically significant association (p < 0.05) with LDL, two loci (11q12 and 20q13) showed association with HDL cholesterol, and two loci (11q12 and 2p24) showed association with triglycerides. The most significant association was between a SNP at 1p13 and LDL cholesterol (p = 4.6 × 10−8). This SNP is in a linkage disequilibrium region containing four genes (CELSR2, PSRC1, MYBPHL, and SORT1) and was recently shown to relate to risk for myocardial infarction. Overall, the results of this study suggest that much of the genetic variation which influences blood lipids is shared across ethnic groups.
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Our chief acknowledgement is to the participants in the Spanish Town Study for their willingness to contribute to the study. We also thank the Research Nurses, Laboratory technologists and drivers at TMRU for their invaluable technical assistance. Investigators of this work were partially supported by grants from the NIH [HL53353 Cooper (PI)]. Genotyping was funded by NIH R01 HL087676 from the NHLBI STAMPEED Genomics Research Program. Replication genotyping was also supported by The Broad Institute Center for Genotyping and Analysis through grant U54 RR020278 from the National Center for Research Resources.
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Gupta, R., Ejebe, K., Butler, J. et al. Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica. Hum Genet 128, 557–561 (2010). https://doi.org/10.1007/s00439-010-0887-3
- African Ancestry
- Linkage Disequilibrium Structure
- Lipid Trait
- Lipid Phenotype
- Linkage Disequilibrium Region