Genetic variants in the renin-angiotensin system genes are associated with cardiovascular-renal-related risk factors in Mexican Americans
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The aim of this study is to examine whether the ACE-I/D, AGT-M235T, and AT1R-A1166C polymorphisms of the renin-angiotensin system (RAS) genes are associated with cardiovascular and renal-related risk factors in Mexican Americans. Study participants (N = 848) were genotyped by Taqman assays. Association analyses were performed by measured genotype approach. Of the phenotypes examined, the ACE-I/D, AGT-M235T, and AT1R-A1166C polymorphisms exhibited significant association with systolic blood pressure, glomerular filtration rate and body mass index, respectively. The data suggest that the polymorphisms examined in the RAS may modulate the risk factors associated with cardiovascular-renal disease.
KeywordsA1166C Polymorphism Family Heart Study Mexican American Population M235T Variant Demographic Data Collection
We thank the members of SAFHS for their participation and cooperation. This study was supported by the Grant-in-Aid from the American Heart Association (FT), Carl W. Gottschalk Research Scholars of the American Society of Nephrology (FT), George O’Brien Kidney Research Center (P50 DK061597; HEA, FT), Genzyme Renal Innovation Program (FT), Norman S. Coplan grant from the Satellite Healthcare (FT). The San Antonio Family Heart Study is supported by NIH grant P01 HL45522. The development of SOLAR was supported by R01 MH59490. This work was supported by the National Center for Research Resources contracts UL1 RR025767 and KL2 RR025766 for the Institute for Integration of Medicine and Science.
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