Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Comments on the paper by D. Li and L. He: Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia

This is a preview of subscription content, log in to check access.

References

  1. Bailar JC III (1997) The promise and problems of meta-analysis. N Engl J Med 337:559–561

  2. Bennett PJ, McMahon WM, Watabe J, Achilles J, Bacon M, Coon H, Grey T, Keller T, Tate D, Tcaciuc I, Workman J, Gray D (2000) Tryptophan hydroxylase polymorphisms in suicide victims. Psychiatr Genet 10:13–17

  3. Berman NG, Parker RA (2002) Meta-analysis: neither quick nor easy. BMC Med Res Methodol 2:10

  4. Bleuler E (1911) Dementia praecox oder Gruppe der Schizophrenien. In: Aschaffenburg G (ed) Handbuch der Psychiatrie, Spez Teil, 4. Deuticke, Leipzig und Wien

  5. Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, Mountain JL, Perez-Stable EJ, Sheppard D, Risch N (2003) The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med 348:1170–1175

  6. Chao HM, Richardson MA (2002) Aromatic amino acid hydroxylase genes and schizophrenia. Am J Med Genet 114:626–630

  7. Chotai J, Serretti A, Lattuada E, Lorenzi C, Lilli R (2003) Gene-environment interaction in psychiatric disorders as indicated by season of birth variations in tryptophan hydroxylase (TPH), serotonin transporter (5-HTTLPR) and dopamine receptor (DRD4) gene polymorphisms. Psychiatry Res 119:99–111

  8. Garver DL, Reich T, Isenberg KE, Cloninger CR (1989) Schizophrenia and the question of genetic heterogeneity. Schizophr Bull 15:421–430

  9. Ingles SA, Haile RW, Henderson BE, Kolonel LN, Nakaichi G, Shi CY, Yu MC, Ross RK, Coetzee GA (1997) Strength of linkage disequilibrium between two vitamin D receptor markers in five ethnic groups: implications for association studies. Cancer Epidemiol Biomarkers Prev 6:93–98

  10. Ioannidis JP, Ntzani EE, Trikalinos TA (2004) ‘Racial’ differences in genetic effects for complex diseases. Nat Genet 36:1312–1318

  11. Jablensky A (2006) Subtyping schizophrenia: implications for genetic research. Mol Psychiatry 11:815–836

  12. Jönsson E, Brene S, Geijer T, Terenius L, Tylec A, Persson ML, Sedvall G (1996) A search for association between schizophrenia and dopamine-related alleles. Eur Arch Psychiatry Clin Neurosci 246:297–304

  13. Jönsson EG, Geijer T, Gyllander A, Terenius L, Sedvall GC (1998) Failure to replicate an association between a rare allele of a tyrosine hydroxylase gene microsatellite and schizophrenia. Eur Arch Psychiatry Clin Neurosci 248:61–63

  14. Kunugi H, Ishida S, Kato T, Sakai T, Tatsumi M, Hirose T, Nanko S (1999) No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patients. Am J Psychiatry 156:774–776

  15. Li D, He L (2006) Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia. Hum Genet 120:22–30

  16. Newton-Cheh C, Hirschhorn JN (2005) Genetic association studies of complex traits: design and analysis issues. Mutat Res 573:54–69

  17. Ohtani M, Shindo S, Yoshioka N (2004) Polymorphisms of the tryptophan hydroxylase gene and serotonin 1A receptor gene in suicide victims among Japanese. Tohoku J Exp Med 202:123–133

  18. Owen MJ (1992) Will schizophrenia become a graveyard for molecular geneticists? Psychol Med 22:289–293

  19. Polymeropoulos MH, Xiao H, Rath DS, Merril CR (1991) Tetranucleotide repeat polymorphism at the human tyrosine hydroxylase gene (TH). Nucleic Acids Res 19:3753

  20. Richardson MA, Read LL, Clelland JD, Chao HM, Reilly MA, Romstad A, Suckow RF (2003) Phenylalanine hydroxylase gene in psychiatric patients: screening and functional assay of mutations. Biol Psychiatry 53:543–553

  21. Rujescu D, Giegling I, Bondy B, Gietl A, Zill P, Moller HJ (2002) Association of anger-related traits with SNPs in the TPH gene. Mol Psychiatry 7:1023–1029

  22. Sand PG, Eichhammer P, Langguth B, Hajak G (2006) COMT Association Data in Schizophrenia: New Caveats. Biol Psychiatry 60:663–664

  23. Serretti A, Lilli R, Lorenzi C, Lattuada E, Cusin C, Smeraldi E (2001) Tryptophan hydroxylase gene and major psychoses. Psychiatry Res 103:79–86

  24. Shinkai T, Ohmori O, Suzuki T, Kojima H, Hori H, Terao T, Nakamura J (2000) Polymorphisms of tryptophan hydroxylase gene and the symptomatology of schizophrenia: an association study. Psychiatr Genet 10:165–171

Download references

Author information

Correspondence to P. G. Sand.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sand, P.G. Comments on the paper by D. Li and L. He: Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia. Hum Genet 122, 409–411 (2007). https://doi.org/10.1007/s00439-007-0383-6

Download citation

Keywords

  • Schizophrenia
  • Personality Disorder
  • Major Depressive Disorder
  • Schizoaffective Disorder
  • Invalid Data