Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

The sexually linked Mpi locus is presumably involved in imidothiazole resistance in Oesophagostomum dentatum parasites

  • 32 Accesses

  • 5 Citations

Abstract

Information about genetic changes during the selection process could indicate mechanisms underlying the spread of resistance to anthelmintic drugs. For clarification of the role of the Mpi locus encoding mannose-phosphate isomerase enzyme in determining resistance, genotyping of Oesophagostomum dentatum strains was performed using an isoelectrofocusing technique. In levamisole- and pyrantel-selected strains the allele associated with resistance has probably been found. Significant values for genetic differentiation between treated and untreated strains of common origin were recorded by Fst indices (θ=0.078; P=0.0008). The specific genomic makeup of a flubendazole-resistant strain, which did not correlate with that of the remaining isolates, might be ascribed to a different action of the anthelmintic or different environmental conditions under which resistance against this drug arose. The absence of heterozygotes in male populations indicated an XX/X0 system of sex determination for the Mpi locus, thus providing a greater potential for the development of resistance. A possible involvement of alleles linked with mannose-phosphate isomerase in alterations of membrane receptors that can be associated with resistance against imidothiazole-based drugs is discussed.

This is a preview of subscription content, log in to check access.

Author information

Additional information

Received: 24 September 1999 / Accepted: 24 November 1999

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Šnábel, V., DeMeeŵs, T., Várady, M. et al. The sexually linked Mpi locus is presumably involved in imidothiazole resistance in Oesophagostomum dentatum parasites. Parasitol Res 86, 486–490 (2000). https://doi.org/10.1007/s004360050698

Download citation

Keywords

  • Selection Process
  • Genetic Differentiation
  • Genetic Change
  • Membrane Receptor
  • Levamisole