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Molecular cloning and expression of an anti-idiotype antibody mimicking a protective oligosaccharide of the parasite Schistosoma mansoni

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Abstract

Genes encoding the heavy and light chains of an anti-idiotype antibody (AB2) mimicking a protective oligosaccharide of Schistosoma mansoni were cloned and expressed as a single-chain Fv fragment. The expression in a functional state was tested using the AB1. A specific binding between sFv and AB1 was observed. Immunization with the recombinant AB2 indicates its capacity to elicit anti-S. mansoni antibodies.

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Received: 28 April 1997 / Accepted: 24 June 1997

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Petitprez, K., Grzych, J., Pierrot, C. et al. Molecular cloning and expression of an anti-idiotype antibody mimicking a protective oligosaccharide of the parasite Schistosoma mansoni . Parasitol Res 84, 38–40 (1997). https://doi.org/10.1007/s004360050353

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Keywords

  • Oligosaccharide
  • Functional State
  • Light Chain
  • Specific Binding
  • Molecular Cloning