The phenotype of cells transporting sporozoites of Eimeria necatrix during a primary infection was determined using a panel of six monoclonal antibodies to various chicken lymphocyte surface markers. Sporozoites and cells harboring them were examined at 8, 12 and 18 h postinfection using two-color immunoflorescence and confocal microscopy. The majority of parasites observed within lymphocytes were found in CD 8+ (15%) or CD 3+ (13–22%) cells at all time periods examined. Smaller numbers were found within δγ TCR+ (5%) and αβ TCR+ (5%) lymphocytes. No sporozoites were found within CD 4+ or IgM+ lymphocytes at any of the time periods.
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Beattie, S., Barta, J. & Fernando, M. Involvement of CD 8+ and CD 3+ lymphocytes in the transport of Eimeria necatrix sporozoites within the intestinal mucosa of chickens. Parasitol Res 87, 405–408 (2001). https://doi.org/10.1007/s004360000371
- Lamina Propria
- Lymphocyte Subpopulation
- Crypt Epithelium
- Crypt Epithelial Cell