In vivo and in vitro antimalarial effect and toxicological evaluation of the chloroquine analogue PQUI08001/06
Antimalarial interventions mostly rely upon drugs, as chloroquine. However, plasmodial strains resistant to many drugs are constantly reported, leading to an expansion of malaria cases. Novel approaches are required to circumvent the drug resistance issue. Here, we describe the antimalarial potential of the chloroquine analogue 2-[[2-[(7-chloro-4-quinolinyl)amino]ethyl]amino] ethanol (PQUI08001/06). We observed that PQUI08001/06 treatment reduces parasitemia of both chloroquine-resistant and -sensitive strains of Plasmodium falciparum in vitro and P. berghei in vivo. Our data suggests that PQUI08001/06 is a potential antimalarial therapeutic alternative approach that could also target chloroquine-resistant plasmodial strains.
KeywordsMalaria Plasmodium Antimalarial drug Chloroquine Chloroquine resistance
We thank the anonymous reviewers for their comments, suggestions, and input which rendered this work more accurate and accessible to the readers. We are grateful to Dr. Erika Martins Braga and Juliana Carvalho Tavares for kindly providing P. berghei strain NK65. The authors are grateful to Dr. Claudio Tadeu Daniel-Ribeiro for kindly providing the P. falciparum strains 3D7 (chloroquine-sensitive) and W2 (chloroquine-resistant).
We thank the following funding agencies for the financial support: CNPq, FAPERJ, PRONEX, PAPES, and Fondazione Ri.MED.
Compliance with ethical standards
Conflict of interests
The authors declare that they have no conflict of interest.
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