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Advanced schistosomiasis reappeared after curing seemingly being cured for over 20 years and without known history of reexposure to Schistosoma japonicum

Abstract

Schistosomiasis is an intravascular disease caused by parasitic trematode worms of the genus Schistosoma. It is estimated that more than 200 million people are infected in the world, and 800 million are at risk of infection. The main lesions are due to eggs trapping in tissue which can lead a series of pathogenic effect relative to immune response. Therefore, killing and eradicating eggs in tissue is often the target to treat schistosomiasis. Here, we report 75 patients who being cured for over 20 years developed into advanced schistosomiasis. A total of 90 patients with a diagnosis of schistosomiasis in various periods were enrolled. Of them, all patients have liver fibrosis, splenectomy was performed in 48.0 %, 42.7 % have splenomegaly, and 30.0 % have portal hypertension. No patients were infected with HBV. Moreover, all patients have not been to Schistosoma-endemic regions. Our results showed that there are other factors leading to schistosomiasis progress besides eggs as well as Schistosoma mansoni.

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References

  1. Allen GPR, Sleigh AC, Li Y, Davis GM, Williams GM, Jiang Z, Feng Z, McManus DP (2001) Clin Microbiol Rev 14:270–295

  2. Bottieau E, Clerinx J, de Vega MR, Van den Enden E, Colebunders R, Van Esbroeck M, Vervoort T, Van Gompel A, Van den Ende J (2006) Imported Katayama fever: clinical and biological features at presentation and during treatment. J Infect 52:339–345

  3. Cheever AW (1968) A quantitative post-mortem study of Schistosomiasis mansoni in man. Am J Trop Med Hyg 17:38–64

  4. Cheever AW, Hoff mann KF, Wynn TA (2000) Immunopathology of schistosomiasis mansoni in mice and men. Immunol Today 21:465–466

  5. Dessein AJ, Hillaire D, Elwali NE, Marquet S, Mohamed-Ali Q, Mirghani A, Henri S, Abdelhameed AA, Saeed OK, Magzoub MM, Abel L (1999) Severe hepatic fibrosis in Schistosoma mansoni infection is controlled by a major locus that is closely linked to the interferon-gamma receptor gene. Am J Hum Genet 65:709–721

  6. Grtseels B, Polderman AM (1987) The morbidity of schistosomiasis mansoni in Maniema (Zaire). Trans R Soc Trop Med Hyg 81:202–209

  7. Homeida M, Ahmed S, Dafalla A, Suliman S, Eltom I, Nash T, Bennett JL (1998) Morbidity associated with Schistosoma mansoni infection as determined by ultrasound: a study in Gezira, Sudan. Am J Trop Med Hyg 39:196–201

  8. Homeida M, Ahmed S, Dafalla A, Suliman S, Eltom I, Nash T, Bennett JL (2000) Morbidity associated with Schistosoma mansoni infection determined by ultrasound in an endemic area of Brazil, Caatinga do Moura. Am J Trop Med Hyg 63:1–4

  9. Lambertucci JR (1993) Acute schistosomiasis: clinical, diagnostic and therapeutic features. Rev Inst Med Trop Sao Paulo 35:399–404

  10. Lei Z-L, Zhou X-N (2015) Eradication of schistosomiasis: a new target and a new task for the National Schistosomiasis Control Programme in the People’s Republic of China. Chin J Schisto Control 27:1–4

  11. Rocha MO, Pedroso ER, Lambertucci JR, Greco DB, Rocha RL, Rezende DF, Neves J (1995) Gastro-intestinal manifestations of the initial phase of schistosomiasis mansoni. Ann Trop Med Parasitol 89:271–278

  12. Ross AG, Vickers D, Olds GR, Shah SM, McManus DP (2007) Katayama syndrome. Lancet Infect Dis 7:218–224

  13. Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J (2006) Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. Lancet Infect Dis 6:411–425

  14. The Cairo Working Group (1992) The use of diagnostic ultrasound in schistosomiasis—attempts at standardization of methodology. Acta Trop 51:45–63

  15. Wu W, Feng A, Huang Y (2015) Research and control of advanced schistosomiasis japonica in China. Parasitol Res 114:17–27

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Acknowledgments

This study is supported by the Jiangsu Provincial Special Fund for Clinical Medicine (No. BL2014020) and the Jiangsu Provincial Commission of Health and Family Planning Applied Fund for Preventing Parasite (X201104).

Author information

Correspondence to Hongxiong Guo.

Additional information

Haiyong Hua and Anhua Yin contributed equally to this work.

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Hua, H., Yin, A., Xu, M. et al. Advanced schistosomiasis reappeared after curing seemingly being cured for over 20 years and without known history of reexposure to Schistosoma japonicum . Parasitol Res 114, 3535–3538 (2015). https://doi.org/10.1007/s00436-015-4616-7

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Keywords

  • Schistosomiasis
  • Schistosoma japonicum
  • Advanced schistosomiasis