Presently, there is a need for increased efforts to develop newer and effective methods to control mosquito vectors as the existing chemical and biological methods are not as effective as in earlier period owing to different technical and operational reasons. The use of nanomaterial products in various sectors of science including health increased during the last decade. We tested three types of nanosilica, namely lipophilic, hydrophilic and hydrophobic, to assess their larvicidal, pupicidal and growth inhibitor properties and also their influence on oviposition behaviour (attraction/deterrence) of mosquito species that transmit human diseases, namely malaria (Anopheles), yellow fever, chickungunya and dengue (Aedes), lymphatic filariasis and encephalitis (Culex and Aedes). Application of hydrophobic nanosilica at 112.5 ppm was found effective against mosquito species tested. The larvicidal effect of hydrophobic nanosilica on mosquito species tested was in the order of Anopheles stephensi > Aedes aegypti > Culex quinquefasciatus, and the pupicidal effect was in the order of A. stephensi > C. quinquefasciatus > Ae. aegypti. Results of combined treatment of hydrophobic nanosilica with temephos in larvicidal test indicated independent toxic action without any additive effect. This is probably the first report that demonstrated that nanoparticles particularly nanosilica could be used in mosquito vector control.
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Aitken RJ, Creely KS, Tran CL (2004) Nanoparticles: an occupational hygiene review. Institute of Occupational Medicine, Edinburgh
Aiub CAF, Coelho ECA, Sodre E, Pinto LFR, Felzenszwalb I (2002) Genotoxic evaluation of the organophosphorous pesticide temephos. Genet Mol Res 101:159–166
Barik TK, Sahu B, Swain V (2008) Nanosilica-from medicine to pest control. Parasitol Res 103(2):253–258
Barjan C, Fedorko A, Kmitowa K (1995) Reactions of entomopathogenic fungi to pesticides. Pol Ecol Stud 21:69–88
Chen M, von Mikecz A (2005) Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles. Exp Cell Res 305:51–62
Drum RW, Gordon R (2003) Star Trek replicators and diatom nanotechnology. Trends Biotechnol 21:325–328
Ferron P (1985) Fungal control. In: Kerkut GA, Gilbert LI (eds) Comprehensive insect physiology, biochemistry and pharmacology. Pergamon, Oxford, pp 313–346
Gordon R, Sterrenburg FAS, Sandhage K (eds) (2005) Special issue on diatom nanotechnology. J Nanosci Nanotechnol 5(1): 1–178
Gordon R, Losic D, Tiffany MA, Nagy SS, Sterrenburg FAS (2009) The Glass Menagerie: diatoms for novel applications in nanotechnology. Trends Biotechnol 27:116–127
Iam NS, Homklinchan C, Larpudomlert R, Warisnoicharoen W (2010) UV irradiation-induced silver nanoparticles as mosquito larvicides. J Appl Sci 10(23):3132–3136
IARC (2007) International Agency for Research on Cancer (IARC). Summaries & Evaluations-SILICA. http://www.inchem.orgldocuments/iarc/vol68/silica.html. Accessed 2 Jun 2007
Jayaseelan C, Rahuman AA, Rajakumar G, Kirthi AV, Santhoshkumar T, Marimuthu S, Bagavan A, Kamaraj C, Zahir AA, Elango G (2011) Synthesis of pediculocidal and larvicidal silver nanoparticles by leaf extract from heartleaf moonseed plant, Tinospora cordifolia Miers. Parasitol Res 109:185–194
Jones N, Ray B, Ranjit KT, Manna AC (2008) Antibacterial activity of ZnO nanoparticle suspensions on a broad spectrum of microorganisms. FEMS Microbiol Lett 279:71–76
Kreyling WG, Semmler M, Erbe F, Mayer P, Takenaka S, Schulz H (2002) Translocation of ultrafine insoluble iridium particles from lung epithelium to extra pulmonary organs is size dependent but very low. J Toxicol Environ Health 65:1513–1530
Laban G, Nies LF, Turco RF, Bickham JW, Sepúlveda MS (2010) The effects of silver nanoparticles on fathead minnow (Pimephales promelas) embryos. Ecotoxicology 19(1):185–195
Marimuthu S, Rahuman AA, Rajakumar G, Santhoshkumar T, Kirthi AV, Jayaseelan C, Bagavan A, Zahir AA, Elango G, Kamaraj C (2011) Evaluation of green synthesized green silver nanoparticles against parasites. Parasitol Res 108:1541–1549
Neethirajan S, Gordon R, Wang L (2009) Potential of silica bodies (phytoliths) for nanotechnology. Trends Biotechnol 27(8):461–467
Parkinson J, Gordon R (1999) Beyond micromachining: the potential of diatoms. Trends Biotechnol 17:190–196
Patil CD, Borase HP, Patil SV, Salunkhe RB, Salunke BK (2012) Larvicidal activity of silver nanoparticles synthesized using Pergularia daemia plant latex against Aedes aegypti and Anopheles stephensi and nontarget fish Poecillia reticulata. Parasitol Res. doi:10.1007/s00436-012-2867-0
Pinhriro VCS, Tadei WP (2002) Evaluation of the residual effect of temephos on Aedes aegypti (Diptera, Culicidae) larvae in artificial containers in Manaus, Amazonas State, Brazil. Cad. Saude Publication 18: 1529–1535
Rajkumar G, Rahuman AA (2011) Larvicidal activity of synthesized silver nanoparticles using Eclipta prostrata leaf extract against filariasis and malaria vector. Acta Trop 118(3):196–203
Salunkhe RB, Patil SV, Patil CD, Salunke BK (2011) Larvicidal potential of silver nanoparticles synthesized using fungus Cochliobolus lunatus against Aedes aegypti (Linnaeus, 1762) and Anopheles stephensi Liston (Diptera; Culicidae). Parasitol Res 109:823–831
Santhoshkumar T, Rahuman AA, Rajakumar G, Marimuthu S, Bagavan A, Jayaseelan C, Zahir AA, Elango G, Kamaraj C (2011) Synthesis of silver nanoparticles using Nelumbo nucifera leaf extract and its larvicidal activity against malaria and filariasis vectors. Parasitol Res 108(3):693–702
Soni N, Prakash S (2012) Efficacy of Chrysosporium tropicum fungus mediated silver and gold nanoparticles against Aedes aegypti larvae. Parasitol Res 110:175–184
Tilak R, Gupta V, Suryam V, Yadav JD, Dutta Gupta KK (2005) A laboratory investigation into oviposition responses of Aedes aegypti to some common household substances and water from conspecific larvae. Med J Armed Forces India 61(3):227–229
Tiwari DK, Behari J (2009) Biocidal nature of treatment of Ag-nanoparticle and ultrasonic irradiation in Escherichia coli dh5. Adv Biol Res 3(3–4):89–95
Ulrichs C, Krause F, Rocksch T, Goswami A, Mewis I (2006) Electrostatic application of inert silica dust based insecticides onto plant surfaces. Commun Agric Appl Biol Sci 71:171–178
World Health Organization (1998) Test procedures for insecticide resistance monitoring in malaria vectors, bio-efficacy and persistence of insecticides on treated surfaces (WHO/CDS/CPC/MAL/98.12). WHO, Geneva
Zhang X, Zhang J, Zhu KY (2010) Chitosan/double-stranded RNA nanoparticle-mediated RNA interference to silence chitin synthase genes through larval feeding in the African malaria mosquito (Anopheles gambiae). Insect Mol Biol 19(5):683–693
Valuable technical assistance provided by Kamal Dev, Narender Kumar and Satpal Singh of NIMR, Delhi is gratefully acknowledged.
The authors declare that they have no competing interests.
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Barik, T.K., Kamaraju, R. & Gowswami, A. Silica nanoparticle: a potential new insecticide for mosquito vector control. Parasitol Res 111, 1075–1083 (2012). https://doi.org/10.1007/s00436-012-2934-6
- Silver Nanoparticle
- Mosquito Species
- Lymphatic Filariasis
- Larval Mortality
- Mosquito Vector