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The efficacy of monepantel, an amino-acetonitrile derivative, against gastrointestinal nematodes of sheep in three countries of southern Latin America

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Abstract

The efficacy of the novel anthelmintic, monepantel (an amino-acetonitrile derivative), was investigated in sheep naturally infected with gastrointestinal nematodes in five studies in Argentina, Brazil, and Uruguay. Monepantel, administered at 2.5 mg/kg liveweight, was highly effective (>99.7%) against Haemonchus contortus, Teladorsagia (Ostertagia) circumcincta, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia curticei, Cooperia mcmasteri, Cooperia oncophora, Cooperia pectinata, Cooperia punctata, and Nematodirus spathiger, including strains resistant to the older broad-spectrum anthelmintics. Efficacy against C. mcmasteri, C. pectinata, and C. punctata is documented for the first time. The treatment with monepantel was well tolerated by the sheep.

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Acknowledgments

The authors wish to thank A. Pinheiro and A. Ferreira (Brazil) and A. Tedesco and his employees (Uruguay) for their assistance in the conduct of these studies. Similarly, Robert Cody is thanked for his critical review and comments on a draft version of this manuscript. The studies were funded by Novartis Animal Health Inc., Basel, Switzerland.

Ethical standards

The experiments were conducted in accordance with the current laws in the respective country.

Author information

Correspondence to Barry C. Hosking.

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Bustamante, M., Steffan, P.E., Bonino Morlán, J. et al. The efficacy of monepantel, an amino-acetonitrile derivative, against gastrointestinal nematodes of sheep in three countries of southern Latin America. Parasitol Res 106, 139–144 (2009). https://doi.org/10.1007/s00436-009-1638-z

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Keywords

  • Levamisole
  • Ivermectin
  • Albendazole
  • Worm Burden
  • Gastrointestinal Nematode