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Study of the Comparative Efficacy of Toltrazuril and Diclazuril against Ovine Coccidiosis in Housed Lambs

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A blinded, controlled and randomised field study was conducted on a sheep farm with a known history of coccidiosis and a high prevalence mainly of the pathogenic coccidium Eimeria ovinoidalis. The efficacy of treatment with toltrazuril (Baycox® 5 % suspension) against natural infections with Eimeria crandallis and/or Eimeria ovinoidalis in housed lambs was investigated in comparison with diclazuril and untreated controls. Both drugs were administered either metaphylactically (i.e., in the prepatency of Eimeria spp.) or therapeutically (after onset of oocyst excretion). A total of 145 animals aged 1 to 5 days at the start of the study were included. Examination of faecal samples was performed every second day between days 13 and 49 of the study. The assessment of treatment efficacy was based mainly on total oocyst excretion and the number of E. crandallis and E. ovinoidalis oocysts (OPG) shed throughout the study. Oocyst excretion was reduced significantly in both groups treated with toltrazuril compared with the untreated control group and with both diclazuril-treated groups. The most prevalent and most severe diarrhoea was observed in the untreated control group. In this study, toltrazuril proved to be highly effective in controlling ovine coccidiosis both metaphylactically and therapeutically. The efficacy of toltrazuril was significantly higher than the efficacy of the control substance with regard to the duration and amount of oocyst excretion, both for the comparison of metaphylactic as well as therapeutic treatment.

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  1. Alzieu JP, Mage C, Maes L, de Mûelenaere C (1999) Economic benefits of prophylaxis with diclazuril against subclinical coccidiosis in lambs reared indoors. Vet Rec 17:442–444.

  2. Amarante AFT, Barbosa MA (1992) Species of coccidia occurring in lambs in Sao Paulo State, Brazil. Vet Parasitol 41:189–193.

  3. Bauer C (1989) Infektion mit Nematodirus battus (Crofton and Thomas, 1951) und Weide-Eimeriose bei Schaflammern in Deutschland. Dtsch Tieraerztl Wochenschr 96:382–384.

  4. Catchpole J, Norton CC, Joyner LP (1976) Experiments with defined multispecific coccidial infections in lambs. Parasitology 72:137–147.

  5. Ernst JV, Benz GW (1981) Coccidiosis. Curr Top Vet Med Anim Sci 6:377–392.

  6. Fitzgerald PR (1980) The economic impact of coccidiosis in domestic animals. Adv Vet Sci Comp Med 24:121–143.

  7. Foreyt WJ (1986) Epidemiology and control of coccidia in sheep. Vet Clin North Am Food Anim Pract 2:383–388.

  8. Gjerde B, Helle O (1986) Efficacy of toltrazuril in the prevention of coccidiosis in naturally infected lambs on pasture. Acta Vet Scand 27:124–137.

  9. Gjerde B, Helle O (1991) Chemoprophylaxis of coccidiosis in lambs with a single oral dose of toltrazuril. Vet Parasitol 38:97–107.

  10. Gregory MW, Joyner LP, Catchpole J, Norton CC (1980) Ovine coccidiosis in England and Wales 1978–1979. Vet Rec 106:461–462.

  11. Gregory MW, Catchpole J (1987) Ovine coccidiosis: pathology of Eimeria ovinoidalis infection. Int J Parasitol 17:1099–1111.

  12. Gregory MW, Catchpole J, Norton CC (1989) Observations on the endogenous stages of Eimeria crandallis in domestic lambs (Ovis aries). Int J Parasitol 19:907–914.

  13. Gregory MW, Catchpole J (1990) Ovine coccidiosis: the pathology of Eimeria crandallis infection. Int J Parasitol 20:849–860.

  14. Haberkorn A, Stoltefuss J (1987) Studies on the activity spectrum of toltrazuril, a new anticoccidial agent. Vet Med Nachr 1:22–32.

  15. Le Sueur C, Mage C, Mundt H-C (2009) Efficacy of toltrazuril (Baycox® 5 % suspension) in natural infections with pathogenic Eimeria spp. in housed lambs. Parasitol Res 104:1157–1162.

  16. Maes L, Coussement W, Vanparijs O, Verheyen F (1989) Species-specific action of diclazuril (Clinacox®) against different Eimeria species in the chicken. In: Coccidia and intestinal coccidiomorphs. Proc. 5th Int. Coccidiosis Conference, Tours, France. INRA, Paris, pp. 259–226.

  17. Mage C, Le Sueur C, Perzo JF (2007) Controle des coccidioses chez des veaux charolais sous la mere par le toltrazuril. Bull GTV 39:111–115.

  18. Mehlhorn H, Ortmann-Falkenstein G, Haberkorn A (1984) The effects of sym. triazinones on developmental stages of Eimeria tenella, E. maxima and E. acervulina: a light and electron microscopical study. Z Parasitenkd 70:173–182.

  19. Mundt H-C, Daugschies A, Uebe F, Rinke M (2003) Efficacy of toltrazuril against artificial infections with Eimeria bovis in calves. Parasitol Res 90:S166–S167.

  20. Mundt H-C, Daugschies A (2007) Current understanding of the epidemiology of intestinal coccidiosis in mammalian livestock. In: Production diseases in farm animals (Ed: Furll M), Merkur Druck und Kopier-Zentrum GmbH, Leipzig, pp. 90–107.

  21. Mundt H-C, Rödder F, Mengel H, Bangoura B, Ocak M, Daugschies A (2007) Control of coccidiosis due to Eimeria bovis and Eimeria zuernii in calves with toltrazuril under field conditions in comparison with diclazuril and untreated controls. Parasitol Res 101:93–104.

  22. Pfister K, Flury B (1985) Coccidiosis in sheep. Schweiz Arch Tierheilkd 127:433–441.

  23. Platzer B, Prosl H, Cieslicki M, Joachim A (2005) Epidemiology of Eimeria infections in an Austrian milking sheep flock and control with diclazuril. Vet Parasitol 129:1–9.

  24. Reeg KJ, Gauly M, Bauer C, Mertens C, Erhardt G, Zahner H (2005) Coccidial infections in housed lambs: oocyst excretion, antibody levels and genetic influences on the infection. Vet Parasitol 127:209–219.

  25. Taylor MA, Catchpole J, Marshall J, Marshall RN, Hoeben D (2003) Histopathological observations on the activity of diclazuril (Vecoxan®) against the endogenous stages of Eimeria crandallis in sheep. Vet Parasitol 116:305–314.

  26. Taylor SM, Kenny J (1988) Coccidiocidal efficacy of a single treatment of toltrazuril in naturally infected lambs. Vet Rec 123:573.

  27. Thienpont D, Roche T, Tole F, Vanparijs OFJ (1990) Diagnose von Helminthosen durch koproskopische Untersuchung. Beerse, Janssen Pharmaceutica.

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Correspondence to Berit Bangoura.

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Mundt, H., Dittmar, K., Daugschies, A. et al. Study of the Comparative Efficacy of Toltrazuril and Diclazuril against Ovine Coccidiosis in Housed Lambs. Parasitol Res 105, 141–150 (2009).

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  • Untreated Control Group
  • Coccidiosis
  • Toltrazuril
  • Eimeria Species
  • Oocyst Excretion