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Risedronate in the treatment of Murine Chagas’ disease

Abstract

Risedronate, a bisphosphonate, was used to treat CD-1 mice infected with the Brazil strain of Trypanosoma cruzi. When given by subcutaneous injection 3 times/week, there was a significant reduction in mortality, however, the myocardial pathology and right ventricular dilation was unchanged in these mice compared to control animals. In C57BL/6 mice infected with the Tulahuen strain, there was no change in mortality in response to risedronate treatment. These data suggest that this class of compounds has activity against T. cruzi in vivo and illustrate the utility of imaging and pathologic studies as adjuncts in the evaluation of therapeutic compounds as treatments for experimental Chagas’ disease. In addition, it underscores the need to use different strains of T. cruzi.

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Acknowledgements

Supported in part by grants from Proctor & Gamble and from the National Institutes of Health AI-062730 (LAJ), AI-12770, AI-052739 and HL-073732 (HBT). We wish to thank Dazhi Zhao and Vitalyi Shtutin for their technical assistance.

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Correspondence to Herbert B. Tanowitz.

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Bouzahzah, B., Jelicks, L.A., Morris, S.A. et al. Risedronate in the treatment of Murine Chagas’ disease. Parasitol Res 96, 184–187 (2005). https://doi.org/10.1007/s00436-005-1331-9

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Keywords

  • Bisphosphonates
  • Risedronate
  • Post Infection
  • Cardiac Magnetic Resonance Imaging
  • Trypanosoma Cruzi