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Quinonic derivatives active against Toxoplasma gondii

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Abstract.

Quinonic derivatives were tested against a virulent RH strain of Toxoplasma gondii maintained in cell culture in THP-1, a human myelomonocytic cell line. The derivatives were tested at various doses (0.5–4 µg/ml) and compared with the reference molecules clindamycine, sulfadiazine, pyrimethamine and atovaquone. The percentage of parasite growth inhibition was observed after 72 h of incubation. The tested derivatives are bicyclic, tricyclic or tetracyclic quinones. Eight of these compounds exhibit over 70% inhibition of parasite growth; and two were nearly equipotent to pyrimethamine. These data indicate that the most active compounds against the RH strain of T. gondii are bis-heterocyclic quinones.

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Sarciron, M., Nebois, P., Pautet, F. et al. Quinonic derivatives active against Toxoplasma gondii . Parasitol Res 88, 969–971 (2002). https://doi.org/10.1007/s00436-002-0615-6

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Keywords

  • Cell Culture
  • Growth Inhibition
  • Quinone
  • Active Compound
  • Tricyclic