Aberrant expression of Sec61α in esophageal cancers

  • Kai Bachmann
  • Maximillian Bockhorn
  • Oliver Mann
  • Florian Gebauer
  • Marco Blessmann
  • Jakob Robert Izbicki
  • Katharina GruppEmail author
Original Article – Cancer Research



The heterotrimeric Sec61α translocon complex is topological located in the membrane of the endoplasmic reticulum (ER) and allows protein transport and calcium across the membrane. Recently, aberrant expression of Sec proteins was linked to carcinogenesis and prognosis of patients.

Materials and methods

Here, we analysed the role of Sec61α in esophageal cancer, and we analysed Sec61α staining on a tissue microarray containing more than 600 esophageal cancer specimens by immunohistochemistry.


Sec61α staining was always strong in benign esophagus, but was only found in 5% of interpretable esophageal adenocarcinomas (EACs) and 14.5% of squamous cell carcinomas (ESCCs). Reduced Sec61α staining was not strongly linked to tumor phenotype in both subgroups of esophageal cancers and was unrelated to clinical outcome of patients (EACs: p = 0.8051 and ESCCs: p = 0.2751).


Thus, Sec61α measurement has not an additional prognostic benefit for the patients.


Sec61α Esophageal cancer Tissue microarray 




Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

The utilization of tissues and clinical data was according to the Hamburger Krankenhaus Gesetz (§12 HmbKHG) and approved by our local Ethical Committee.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.General, Visceral and Thoracic Surgery Department and ClinicUniversity Medical Center Hamburg-EppendorfHamburgGermany
  2. 2.Department of Plastic, Reconstructive and Aesthetic SurgeryUniversity Medical Center Hamburg-EppendorfHamburgGermany

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