Chinese guidelines for the diagnosis and comprehensive treatment of colorectal liver metastases (version 2018)

  • Jianmin XuEmail author
  • Jia Fan
  • Xinyu Qin
  • Jianqiang Cai
  • Jin Gu
  • Shan Wang
  • Xishan Wang
  • Suzhan Zhang
  • Zhongtao Zhang
  • China CRLM Guideline Group
Original Article – Clinical Oncology


The liver is the most common anatomical site for hematogenous metastases of colorectal cancer, and colorectal liver metastases is one of the most difficult and challenging points in the treatment of colorectal cancer. To improve the diagnosis and comprehensive treatment in China, the Guidelines have been edited and revised several times since 2008, including the overall evaluation, personalized treatment goals and comprehensive treatments, to prevent the occurrence of liver metastases, improve the resection rate of liver metastases and survival. The revised Guideline includes the diagnosis and follow-up, prevention, MDT effect, surgery and local ablative treatment, neoadjuvant and adjuvant therapy, and comprehensive treatment, and with advanced experience, latest results, detailed content, and strong operability.


Colorectal neoplasms Liver metastases Diagnosis Comprehensive treatment Guideline 



The members of China CRLM Guideline Group are Yi Ba, Jianhong Bu, Jianhui Cai, Sanjun Cai, Shan Zeng, Zhaochong Zeng, Gong Chen, Yu Chen, Zihua Chen, Zongyou Chen, Jiemin Cheng, Pan Chi, Guanghai Dai, Yong Dai, Yanhong Deng, Kefeng Ding, Xuedong Fang, Chuangang Fu, Jianping Gong, Chunyi Hao, Yulong He, Zhongcheng Huang, Jiafu Ji, Baoqing Jia, Kewei Jiang, Jing Jin, Dalu Kong, Ping Lan, Dechuan Li, Guoli Li, Jin Li, Leping Li, Yunfeng Li, Zhixia Li, Houjie Liang, Xiaobo Liang, Feng Lin, Jianjiang Lin, Hongjun Liu, Tianshu Liu, Yunpeng Liu, Hongming Pan, Zhizhong Pan, Haiping Pei, Tao Peng, Li Ren, Lin Shen, Chun Song, Tianqiang Song, Xiangqian Su, Yihong Sun, Min Tao, Liguo Tian, Desen Wan, Jianping Wang, Guiying Wang, Guiyu Wang, Haijiang Wang, Jianhua Wang, Lei Wang, Xin Wang, Yajie Wang, Yi Wang, Ziqiang Wang, Ye Wei, Dong Wei, Feng Xia, Jianguo Xia, Lijian Xia, Baocai Xing, Bin Xiong, Jianming Xu, Nong Xu, Ruihua Xu, Ye Xu, Zekuan Xu, Zhongfa Xu, Shujun Yang, Hongwei Yao, Yingjiang Ye, Peiwu Yu, Ying Yuan, Jun Zhang, Keliang Zhang, Wei Zhang, Xiaotian Zhang, Yanqiao Zhang, Youcheng Zhang, Zhen Zhang, Qingchuan Zhao, Ren Zhao, Shu Zheng, Aiping Zhou, Jian Zhou, Zongguang Zhou.



Compliance with ethical standards

Conflict of interest

The author(s) declare that they have no competing interests.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Supplementary material

432_2018_2795_MOESM1_ESM.docx (48 kb)
Supplementary material 1 (DOCX 47 KB)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Colorectal Surgery, Zhongshan HospitalFudan UniversityShanghaiChina
  2. 2.Colorectal Cancer Center, Zhongshan HospitalFudan UniversityShanghaiChina
  3. 3.Shanghai Engineering Research Center of Colorectal Cancer Minimally InvasiveShanghaiChina
  4. 4.Department of Liver Surgery, Liver Cancer Institute, Zhongshan HospitalFudan UniversityShanghaiChina
  5. 5.Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of EducationShanghaiChina
  6. 6.Department of Hepatobiliary Surgery, National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  7. 7.Gastrointestinal Cancer CenterPeking University Cancer Hospital, Key Laboratory of Carcinogenesis and Translational Research, Ministry of EducationBeijingChina
  8. 8.Peking-Tsinghua Center for Life SciencesBeijingChina
  9. 9.Peking University Shougang HospitalBeijingChina
  10. 10.Department of Gastroenterological Surgery, Laboratory of Surgical OncologyBeijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s HospitalBeijingChina
  11. 11.Department of Colorectal Surgery, Cancer Institute and HospitalChinese Academy of Medical Sciences, Peking Union Medical CollegeBeijingChina
  12. 12.Cancer InstituteKey Laboratory of Cancer Prevention and Intervention, Ministry of EducationHangzhouChina
  13. 13.The Second Affiliated Hospital, School of MedicineZhejiang UniversityHangzhouChina
  14. 14.Department of General Surgery, Beijing Friendship HospitalCapital Medical UniversityBeijingChina
  15. 15.Beijing Key Laboratory of Cancer Invasion and Metastasis Research and National Clinical Research Center for Digestive DiseasesBeijingChina

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