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FDG PET/CT to predict the curability of endoscopic resection for early gastric cancer

  • Hyun Woo Chung
  • Jeong Hwan KimEmail author
  • In-Kyung Sung
  • Sun-Young Lee
  • Hyung Seok Park
  • Chan Sup Shim
  • Ho Yoon Bang
  • Young So
  • Eun Jeong Lee
Original Article – Clinical Oncology
  • 57 Downloads

Abstract

Purpose

We evaluated the value of fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) as a complementary imaging modality to endoscopy to predict the curability of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC).

Methods

The institutional review board approved this retrospective study with a waiver of informed consent. The records of patients who underwent FDG PET/CT for initial routine staging of gastric cancer from January 2012 to October 2017 were reviewed retrospectively. Among them, the patients who had EGC with well or moderately differentiated adenocarcinoma were included in this study. A total of 210 EGCs in 199 patients (mean age ± SD, 67 ± 10 years) were selected for this study. For the analysis of FDG PET/CT image, the radiotracer uptake by the primary tumor was compared with the background gastric uptake. Each case was classified as curable by ESD (no discrete radioactivity) and not curable by ESD (discrete radioactivity).

Results

The detection rate of EGC by FDG PET/CT was 37.1% (78 discrete radioactivity in 210 EGCs). However, for the detection of EGC that is not curable by ESD, the sensitivity, specificity, positive predictive value, negative predictive value, and area under the receiver operating characteristic curve with 95% confidence intervals were 79% (67–87%), 91% (85–95%), 81% (71–88%), 89% (84–93%), and 0.85 (0.79–0.89), respectively.

Conclusion

FDG PET/CT may be a useful complementary imaging modality to endoscopy to predict the curability of ESD for EGC.

Keywords

Early gastric cancer Endoscopic submucosal dissection Endoscopic resection FDG PET/CT 

Notes

Compliance with ethical standards

Ethical statement

This study was reviewed by the appropriate Ethics Committee and was, therefore, performed in accordance with the ethical standards laid down in the Declaration of Helsinki revised in Brazil 2013.

Informed consent

This retrospective study was waived from the need to obtain informed consent by our Institutional Review Board (KUH1280106).

Conflict of interest

Hyun Woo Chung, Jeong Hwan Kim, In-Kyung Sung, Sun-Young Lee, Hyung Seok Park, Chan Sup Shim, Ho Yoon Bang, Young So, and Eun Jeong Lee declare that they have no conflicts of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Hyun Woo Chung
    • 1
  • Jeong Hwan Kim
    • 2
    Email author return OK on get
  • In-Kyung Sung
    • 2
  • Sun-Young Lee
    • 2
  • Hyung Seok Park
    • 2
  • Chan Sup Shim
    • 2
  • Ho Yoon Bang
    • 3
  • Young So
    • 1
  • Eun Jeong Lee
    • 4
  1. 1.Department of Nuclear MedicineKonkuk University Medical Center, Konkuk University School of MedicineSeoulSouth Korea
  2. 2.Department of Internal MedicineKonkuk University Medical Center, Konkuk University School of MedicineSeoulSouth Korea
  3. 3.Department of SurgeryKonkuk University Medical Center, Konkuk University School of MedicineSeoulSouth Korea
  4. 4.Department of Nuclear MedicineSeoul Medical CenterSeoulSouth Korea

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