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Effect of smoking cessation counseling within a randomised study on early detection of lung cancer in Germany

Abstract

Introduction

In the German lung cancer screening trial LUSI, smoking cessation counseling (SCC) was offered to all participants at time of randomization, and smoking habits were asked for within annual questionnaire inquiries. We analyzed the smoking habits of the participants within the first 2 years of follow-up and especially the potential effect of the SCC on these habits.

Materials and methods

We used the smoking data of the initial inquiry on which the decision on invitation to the study was based, the socio-economic data of the questionnaire filled-in at time of randomization, the psycho-social data obtained during the SCC, and the annual questionnaire data of the first two annual follow-up screening rounds.

Results

Smoking prevalence decreased in the entire cohort significantly by 4 %, whereby the decrease was with 4.5 % statistically not significantly higher in the control arm than in the screening arm with 3.4 %. The decline was much stronger in the subgroup of attendees to stop-smoking counseling and mounted up therein to 10 %. In some participants, an increase of readiness to quit smoking was observed during the counseling hour, but did not show effects on smoking status 2 years later.

Discussion

We did not see a tendency to increased smoking among participants of the intervention arm or the entire study. The decline of smoking prevalence among the attendees of the counseling might be due to self-selection. Since the issue of effectiveness of smoking cessation counseling is important, further research with randomization into offering counseling or no intervention should be taken into consideration.

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Acknowledgments

We thank S. Roether who set up and administered the database, the technical staff (S. Albrecht, A. Bari, U. Beckhaus, K. Lenner-Fertig), the screening radiologists (S. Delorme, J. Tremper, M. Eichinger, D.-E. Optazaite, M. Puderbach), the physicians of the Thorax Hospital (C.P. Heussel, H. Dienemann,) and the pathologist (P.A. Schnabel). The study was funded by the Dietmar Hopp Foundation (2007–2010) and the German Research Association (2007–2013).

Funding

This study was funded by DFG BE2486 and Dietmar Hopp Stiftung DL-26.01.07.

Author information

Correspondence to N. Becker.

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Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Bade, M., Bähr, V., Brandt, U. et al. Effect of smoking cessation counseling within a randomised study on early detection of lung cancer in Germany. J Cancer Res Clin Oncol 142, 959–968 (2016). https://doi.org/10.1007/s00432-015-2105-0

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Keywords

  • Low-dose CT
  • LUSI
  • MSCT
  • Multislice CT
  • Quit smoking
  • Screening