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The prognostic significance of HOTAIR for predicting clinical outcome in patients with digestive system tumors



Although some studies have assessed the prognostic value of HOTAIR in patients with digestive system tumors, the relationship between the HOTAIR and outcome of digestive system tumors remains unknown.


The PubMed was searched to identify the eligible studies. Here, we performed a meta-analysis with 11 studies, including a total of 903 cases. Pooled hazard ratios (HRs) and 95 % confidence interval (CI) of HOTAIR for cancer survival were calculated.


We found that the pooled HR elevated HOTAIR expression in tumor tissues was 2.36 (95 % CI 1.88–2.97) compared with patients with low HOTAIR expression. Moreover, subgroup analysis revealed that HOTAIR overexpression was also markedly associated with short survival for esophageal squamous cell carcinoma (HR 2.19, 95 % CI 1.62–2.94) and gastric cancer (HR 1.66, 95 % CI 1.02–2.68). In addition, up-regulated HOTAIR was significantly related to survival of digestive system cancer among the studies with more follow-up time (follow time ≥ 5 years) (HR 2.51, 95 % CI 1.99–3.17). When stratified by HR resource and number of patients, the result indicated consistent results with the overall analysis. Subgroup analysis on ethnicities did not change the prognostic influence of elevated HOTAIR expression. Additionally, we conducted an independent validation cohort including 71 gastric cancer cases, in which patients with up-regulated HOTAIR expression had an unfavorable outcome with HR of 2.10 (95 % CI 1.10–4.03).


The results suggest that aberrant HOTAIR expression may serve as a candidate positive marker to predict the prognosis of patients with carcinoma of digestive system.

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This study was partly supported by National Natural Science Foundation of China (81473050, 81473049 and 81230068), the Key Program for Basic Research of Jiangsu Provincial Department of Education (12KJA330002), Jiangsu Provincial Science and Technology Innovation Team, Collaborative Innovation Center For Cancer Personalized Medicine, and the Priority Academic Program Development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine).

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Correspondence to Zhengdong Zhang or Jian Wang or Weida Gong.

Additional information

Gaoxiang Ma, Qiaoyan Wang and Chunye Lv have contributed equally to this work.

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Ma, G., Wang, Q., Lv, C. et al. The prognostic significance of HOTAIR for predicting clinical outcome in patients with digestive system tumors. J Cancer Res Clin Oncol 141, 2139–2145 (2015).

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  • Prognosis factor
  • Digestive system tumors