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Procalcitonin as a predictive marker of infections in chemoinduced neutropenia

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Abstract

Purpose

This study was designed to determine the usefulness of procalcitonin (PCT) as a predictive marker of infections in neutropenic patients following chemotherapeutic treatments.

Methods

Over a 6-month period, 65 patients (34 affected by a solid tumor, 31 by a hematological disorder) were enrolled. Serum PCT concentrations were measured by an automated immunoassay on the leucocytes nadir and on the third day, when patients were checked for any sign of infection.

Results

Procalcitonin values were not affected by gender, age, therapeutic approach, use of G-CSF or performance status and did not differ between patients who subsequently developed a localized infection and those who did not. PCT concentrations resulted higher in patients affected by hematological disorders than in those affected by solid tumors (mean value 0.09 vs. 0.05 μg/L; p < 0.0015) and in those who were hospitalized than in the outpatient group (0.10 vs. 0.05 μg/L; p < 0.0013). PCT levels correlated with the type of neoplastic disease (p = 0.016), the highest concentrations being detected in patients affected by acute leukemia.

Conclusions

These findings suggest that PCT is not a useful predictive marker of infection in oncohematologic neutropenic patients, even though higher serum PCT concentrations are associated with hematological tumors as well as in-hospital admission.

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Conflict of interest statement

None among the authors of the article has any financial and personal relationships with other people or organisations that could inappropriately influence the presented work.

Author information

Correspondence to Giulio Mengozzi.

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Carnino, L., Betteto, S., Loiacono, M. et al. Procalcitonin as a predictive marker of infections in chemoinduced neutropenia. J Cancer Res Clin Oncol 136, 611–615 (2010). https://doi.org/10.1007/s00432-009-0699-9

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Keywords

  • Procalcitonin
  • Neutropenia
  • Infection markers
  • Chemotherapy