We report on the clinical, laboratory, and molecular genetic findings in a 15-month-old boy who initially presented with disseminated cytomegalovirus and concomitant para-influenza virus infection. Hyper-IgM syndrome, suspected on clinical grounds, was confirmed by immunological investigations. In addition, a previously unreported potentially disease-causing mutation in the CD40 ligand gene was detected in this patient.
Conclusion The present case illustrates that disseminated cytomegalovirus infection with atypical clinical features should be included in the spectrum of the hyper-IgM syndrome.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Received: 18 August 1999 and in revised form: 26 October 1999 / Accepted: 4 January 2000
About this article
Cite this article
Benesch, M., Pfleger, A., Eber, E. et al. Disseminated cytomegalovirus infection as initial manifestation of hyper-IgM syndrome in a 15-month-old boy. Eur J Pediatr 159, 453–455 (2000). https://doi.org/10.1007/s004310051306
- Key words Cytomegalovirus
- Para-influenza virus
- Hyper-IgM syndrome
- CD40 ligand gene
- AbbreviationsCD40L CD40 ligand
- CMV cytomegalovirus
- HIM hyper-IgM