Oral vitamin A for prevention of bronchopulmonary dysplasia
First, an error has been noted in sample size calculation. The authors have calculated a sample size of 178 using online power/sample size calculator (http://www.stat.ubc.ca/~rollin/stats/ssize/b2.html). However, the sample size was much higher (n = 452) when recalculated using the above mentioned calculator. We tried to calculate the power for the specified sample, which came out as 45%.
Another concern is that the total duration (median as well as the inter-quartile range) of CPAP and oxygen requirement is much less as compared with the incidence of oxygen requirement at 28 days. Whether this total duration of oxygen requirement included the days on mechanical ventilation or on CPAP?
Lastly, the osmolality of the aqueous oral vitamin A solution used in the trial is not mentioned, since osmolality is a key factor that needs to be taken into consideration when choosing an oral solution for preterm infants . This becomes more important in light of four times the incidence of necrotizing enterocolitis in the control group though it was not statistically significant.
Dr. Bharti Yadav: drafted the initial manuscript and approved the final manuscript as submitted.
Dr. Rohit Sasidharan: revised and critically reviewed the manuscript and approved the final manuscript as submitted.
Dr. Neeraj Gupta: critically reviewed the manuscript and approved the final manuscript as submitted.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
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