Dilated cardiomyopathy in a national paediatric population
Dilated cardiomyopathy is the most common form of childhood cardiomyopathy and is known to result in significant morbidity and mortality. This study aims to review the aetiology and associated outcomes of DCM. The median age at diagnosis was 6 months (0–42 months); n = 23 (43.3%) were idiopathic; n = 11 (20.9%) secondary to a viral infection; n = 12 (22.6%) genetic disorders and n = 7 (13.2%) as a result of vitamin D deficiency. There was a significant correlation between aetiology and mortality, r = 0.85, with a lower survival rate in idiopathic and genetic cohorts. Males were significantly less likely to survive to 1 year of age, p = 0.035. The age at diagnosis did not alter survival to 1 year and the predicted survival beyond 1 year was 84.3% (95% CI, 71.3 to 94.5%). Severely impaired left ventricular fractional shortening at presentation (< 15%) was an independent predictor of death, p = 0.002, (95% CI, 11.2 to 14.2%).
What is Known:
•Paediatric dilated cardiomyopathy (DCM) is the commonest of the childhood cardiomyopathies, with significant associated morbidity and mortality.
•DCM is most commonly idiopathic.
What is New:
•Identifying the aetiology of DCM in the paediatric population aids risk stratification and prognostication.
•The first year after diagnosis of DCM is associated with significant mortality.
KeywordsDilated cardiomyopathy Myocarditis Vitamin D deficiency
Extra-corporeal life support
Polymerase chain reaction
Sudden cardiac death
Scottish Index of Multiple Deprivation
Dr. Jammal Addin conceptualized and designed the study, drafted the manuscript, interpreted the data and completed all subsequent revisions until submission; Dr. Young carried out the statistical analysis and critically reviewed the manuscript; Dr. McCarrison assisted with drafting the manuscript, the design and conduct of the study; Dr. Hunter conceptualized and designed the study, advised in presentation of analysis results, and revised the drafts critically for important intellectual content. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.
Compliance with ethical statements
Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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