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European Journal of Pediatrics

, Volume 178, Issue 1, pp 81–87 | Cite as

Increased serum Th2 chemokine levels are associated with bronchopulmonary dysplasia in premature infants

  • Dan Zhou
  • Fang Shi
  • Ying Xiong
  • Min Zhou
  • Huajing WanEmail author
  • Hanmin LiuEmail author
Original Article

Abstract

Bronchopulmonary dysplasia (BPD) is one of the most common chronic inflammatory lung disease of premature infants, with serious short- and long-term consequences. Early identification of premature infants at risk of BPD is critical to preventing the pathogenesis of disease. Thus, in the present study, we recruited 126 premature infants, collected peripheral blood samples at different time points during early life, and measured the concentration of Th1 (MCP-1, IP-10, and MIG) and Th2 (eotaxin-1, eotaxin-2, and MCP-4) chemokines in serum. We found serum eotaxin-2 levels were significantly higher in the BPD group than in the non-BPD group on day 1 [1662 pg/ml vs. 1221 pg/ml, P < 0.05], day 7 [1533 pg/ml vs. 1089 pg/ml, P < 0.05], and day 14 [1246 pg/ml vs. 704 pg/ml, P < 0.05] after birth, and serum MCP-4 levels were also significantly higher in the BPD group than in the non-BPD group on day 1 [186 pg/ml vs. 128 pg/ml, P < 0.05], day 7 [199 pg/ml vs. 101 pg/ml, P < 0.05], and day 14 [238 pg/ml vs. 106 pg/ml, P < 0.05] of life.

Conclusions: Increased levels of Th2 chemokines, eotaxin-2, and MCP-4, are associated with BPD in premature infants.

What is Known:

The pathogenesis of BPD is multifactorial and it is difficult to predict and prevent.

Previous studies have demonstrated that inflammation plays a major role in the pathogenesis of BPD.

What is New:

Increased Th2 chemokines, eotaxin-2 and MCP-4, were associated with BPD in premature infants.

Abnormal Th1/Th2 response in early life maybe associated with the subsequent development of BPD, which provide a new insight to understand the pathogenesis of the disease.

Keywords

Biomarker Bronchopulmonary dysplasia Inflammation Premature infants Th1/Th2 chemokines 

Abbreviations

BPD

bronchopulmonary dysplasia

ELBW

extremely low birth weight

IP

interferon (IFN) gamma-induced protein

MCP

monocyte chemotactic protein

MIG

monokine induced by interferon-γ

Th

T helper type

Notes

Acknowledgments

The authors thank the study participants and their parents. In addition, the authors gratefully acknowledge the support from the National Key R&D Program of China (No. 2017YFC0211705) and the National Natural Science Foundation of China (No. 81601326).

Authors’ contributions

Participated in research design: Hanmin Liu, Huajing Wan, and Dan Zhou.

Conducted experiments: Dan Zhou and Fang Shi.

Performed data analysis: Fang Shi, Ying Xiong, and Min Zhou.

Wrote or contributed to the writing of the manuscript: Dan Zhou, Fang Shi, and Hanmin Liu.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants’ parents included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.The Vascular Remodeling and Developmental Defects Research Unit, West China Institute of Women and Children’s Health, West China Second University HospitalSichuan UniversityChengduChina
  2. 2.Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University HospitalSichuan UniversityChengduChina
  3. 3.Maternal Child Information Office, Chengdu Shuangliu District Maternal and Child Health HospitalChengduChina
  4. 4.Chengdu Newgenegle Biotech Co. Ltd.ChengduChina
  5. 5.Department of Pediatric Pneumology, West China Second University HospitalSichuan UniversityChengduChina

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