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Polymorphism rs2239185 in vitamin D receptor gene is associated with severe community-acquired pneumonia of children in Chinese Han population: a case-control study


Vitamin D receptor (VDR) is a potential candidate gene for community-acquired pneumonia (CAP). Examining the susceptibility VDR gene for CAP is essential for early intervention, prevention of related complications, and improvement of outcome. A case-control study was performed to examine the association between rs2239185 of VDR gene and CAP among children in Chinese Han population. Polymerase chain reaction and direct sequencing were used to genotype rs2239185 in 91 CAP children and 94 healthy children. For rs2239185, individuals with TT genotype showed a significantly higher risk of CAP than those with CC plus CT genotypes (P = 0.008). The occurrence of T allele of rs2239185 was significantly more frequent in CAP children than those in normal controls (P = 0.045).We found through stratification analysis that CAP children with systemic inflammatory response syndrome (SIRS), leukocyte count (WBC) >10 × 109/L, C-reactive protein (CRP) >25 mg/L, procalcitonin (PCT) >2 ng/mL, and pediatric critical illness score <80 scores showed significantly higher frequency of TT genotype than those in normal controls (P = 0.0012, 0.0035, 0.0005, 0.0002, and 0.0021, respectively).

Conclusion: TT genotype of rs2239185 in VDR gene might be one of the potential genetic risk factors for CAP, and T allele of rs2239185 might be associated with the susceptibility to CAP and the severity of CAP.

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Fig. 1



Community-acquired pneumonia


Confidence intervals


C-reactive protein


Odds ratios


Pediatric critical illness score


Polymerase chain reaction




Systemic inflammatory response syndrome


Single nucleotide polymorphisms


Vitamin D receptor


Leukocyte count


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At the point of finishing this paper, I would like to express my sincere thanks to all those who have lent me hands in the course of my writing this paper. First of all, I would like to take this opportunity to show my sincere gratitude to my supervisor, Mrs Zhang, who has given me so much useful advices on my writing and has tried her best to improve my paper. Secondly, I would like to express my gratitude to my teachers who offered me references and information on time. Without their help, it would be much harder for me to finish my study and this paper.

Conflict of interest

We declare that we have no conflicts of interest.

Ethical standards

The protocols for the study and the written consent were approved by the ethics committee of Capital Institute of Pediatrics at Beijing, China (Approval ID SHERLL 2013075), and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Author information

Correspondence to Jianhua Wang or Qi Zhang.

Additional information

Wei Li and Linying Guo contributed equally to this work.

Communicated by David Nadal

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Li, W., Guo, L., Li, H. et al. Polymorphism rs2239185 in vitamin D receptor gene is associated with severe community-acquired pneumonia of children in Chinese Han population: a case-control study. Eur J Pediatr 174, 621–629 (2015).

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  • Vitamin D receptor
  • Community-acquired pneumonia
  • rs2239185
  • SIRS