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Chemical pleurodesis using a Viscum album extract in infants with congenital chylothorax

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Congenital chylothorax is a rare condition, but it is the most common cause of pleural effusion in neonates and infants. Here, we report on the first trials of the intrapleural instillation of an extract of Viscum album (European mistletoe) (Abnobaviscum Q®) in two infants with congenital chylothorax that was refractory to standard conservative management and thoracic duct ligation. Conclusion: The clinical course of both children improved with no side effects related to the extract after following up the children for 2 years and 9 months, respectively. Randomized multicenter prospective studies will help determine the effectiveness of pleurodesis with a V. album extract and the occurrence of long-term side effects with this agent.

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Conflict of interest

The authors have no conflicts of interest to disclose.

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Correspondence to In Seok Jeong.

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Communicated by Willem Proesmans

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Cho, H.J., Na, K.J., Kim, D.W. et al. Chemical pleurodesis using a Viscum album extract in infants with congenital chylothorax. Eur J Pediatr 173, 823–826 (2014). https://doi.org/10.1007/s00431-014-2283-9

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  • Congenital chylothorax
  • Pleurodesis
  • Viscum album
  • Mistletoe extract