European Journal of Pediatrics

, Volume 173, Issue 5, pp 681–683 | Cite as

Anti-N-methyl-d-aspartate receptor encephalitis in a pre-teenage girl: a case report

  • Stephanie Nijmeijer
  • Sander Bontemps
  • Leonie Naeije
  • Jonathan CoutinhoEmail author
Case Report


Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is an auto-immune and paraneoplastic encephalitis which generally affects young adults. It is a multistage illness, with prominent extrapyramidal, neuropsychiatric and autonomic symptoms. The syndrome is frequently associated with an ovarian teratoma. Recently, it has become evident that anti-NMDAR encephalitis is more common in children and adolescents than was previously believed. Prognostic factors that determine a good outcome are presence of a tumour, prompt treatment and no need for admission to an intensive care unit. Increased awareness among paediatricians of this potentially life-threatening disease is important because early recognition and treatment will improve the patients’ chances of a good clinical outcome. In this case report, we describe a 9-year-old girl with behavioural changes and severe extrapyramidal symptoms due to anti-NMDAR encephalitis associated with an ovarian teratoma. She was treated with a variety of immunomodulating therapies and made a slow, but good recovery.


Anti-N-methyl-d-aspartate receptor Encephalitis Teratoma Children 



Anti-N-methyl-d-aspartate receptor


Cerebrospinal fluid


N-methyl-d-aspartate receptor


Paediatric intensive care unit



The parents of the patient gave informed consent for publication of this case report.

Conflict of Interest

The authors declare that they have no competing interests.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Stephanie Nijmeijer
    • 1
  • Sander Bontemps
    • 2
  • Leonie Naeije
    • 3
  • Jonathan Coutinho
    • 4
    Email author
  1. 1.Academic Medical CentreUniversity of AmsterdamAmsterdamThe Netherlands
  2. 2.Department of Pediatric Intensive Care, Academic Medical Centre, Emma Children’s HospitalUniversity of AmsterdamAmsterdamThe Netherlands
  3. 3.Department of Pediatrics, Academic Medical Centre, Emma Children’s HospitalUniversity of AmsterdamAmsterdamThe Netherlands
  4. 4.Department of Neurology, Academic Medical CentreUniversity of AmsterdamAmsterdamThe Netherlands

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