Abstract
In order to prepare growth references for height, weight, and head circumference for Argentine children with Achondroplasia, 228 children (114 boys) aged 0–18 years attending the Growth Clinic at Hospital Garrahan were measured between 1992 and 2009. Centiles were calculated by LMS, a method for summarizing growth data which adjusts for skewness. Curves for centiles are obtained using the formula: \( {{\hbox{C}}_{{100}}}_\alpha (t){ = }M(t){\left( {{1 + }L(t)S(t){Z_\alpha }} \right)^{{1/}L(t)}} \), where Z α is the normal equivalent deviate for tail area α; C100α is the weight or height centile corresponding to Z α , t is age in years, and L(t) is (skewness)(t), M(t) is median, S (t) is coefficient variation and C100α (t) indicates the corresponding values of each curve at age t. Boys and girls centiles for height were similar to USA references in infancy and childhood but lower than that references at adolescence. Final height was 1.7 and 5.1 cm below USA achondroplasia references in girls and boys, respectively. Head circumference centiles were, at all ages, lower than USA references in both genders. Countries need national references for clinical growth assessment of their local population. Likewise, specific local growth references for children with some genetic conditions (such us achondroplasia) are valuable tools for detecting additional conditions affecting growth, for estimating final height and for evaluating the impact of growth-promoting treatments. Conclusion: references presented here can also be used in other countries with similar ethnographics characteristics.
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References
Alsina JA (2008) La inmigración Europea en la Republica Argentina. Biblio Bazaar
Bellus GA, Hefferon TW, Ortiz de Luna RI et al (1995) Achondroplasia is defined by recurrent G380R mutations of FGFR3. Am J Hum Genet 56:368–373
Caíno S, Adamo P, Kelmansky D, Lejarraga H (2002) Impacto del entrenamiento sobre el error de mediciones antropométricas. Arch Argent Pediatr 100:110–113
Caíno S, Kelmansky D, Adamo P, Lejarraga H (2010) Short-term growth in head circumference and its relationship with supine length in healthy infants. Ann Hum Biol 37:108–116
Cole TJ (1988) Fitting smoothed centile curves to reference data. J R Stat Soc (A) 151:354–418
Cole TJ, Green PJ (1992) Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med 11:1305–1319
Eveleth PB, Tanner JM (1990) Worldwide variation in human growth. 2e. Great Britain Cambridge University Press
Garcia Rudaz C, Martinez AS, Heinrich JJ et al (1995) Growth of Argentinean girls with Turner syndrome. Ann Hum Biol 22:533–544
Hecht JT, Hood OJ, Schwartz RJ et al (1988) Obesity in achondroplasia. Am J Med Genet 31:597–602
Hoover-Fong JE, McGready J, Schulze KJ et al (2007) Weight for age charts for children with achondroplasia. Am J Med Genet A 143A:2227–2235
Hoover-Fong JE, Schulze KJ, McGready J et al (2008) Age-appropriate body mass index in children with achondroplasia: interpretation in relation to indexes of height. Am J Clin Nutr 88:364–371
Horton WA, Rotter JI, Rimoin DL et al (1978) Standard growth curves for achondroplasia. J Pediatr 93:435–438
Hunter AG, Hecht JT, Scott Cl Jr (1996) Standard weight for height curves in achondroplasia. Am J Med Genet 62:255–261
INDEC (2001) Censo Nacional de Población, Hogares y Vivienda 2001. Serie 2—Resultados Generales. Total del país. Instituto nacional de estadísticas y censos. Buenos Aires. Argentina, vol 25
Kao SC, Waziri MH, Smith WL et al (1989) MR imaging of the craniovertebral junction, cranium and brain in children with achondroplasia. AJR Am J Roentgenol 153:565–569
Kuczmarski RJ, Ogden CL, Grummer-Strawn LM et al (2000) CDC growth charts: United States. Adv Data 8:1–27
Kuczmarski RJ, Ogden CL, Guo SS et al (2002) 2000 CDC Growth Charts for the United States: methods and development. Vital Health Stat 11:1–190
Lejarraga H (1992) Uso de estándares nacionales e internacionales de crecimiento: un falso dilema. Arch Argent Pediatr 80:364–368
Lejarraga H, del Pino M, Fano V et al (2009) Growth references for weight and height for Argentinean girls and boys from birth to maturity: incorporation of data from the World Health Organization from birth to 2 years and calculation of new percentiles and LMS values. Arch Argent Pediatr 107:126–133
Lejarraga H, Díaz Ballvé C, Guerro A (1976) Estudio antropométrico de 1401 recién nacidos sanos del área urbana de Buenos Aires. Rev Hosp NinÄos 18:9–21
Lejarraga H, Heinrich JJ, Rodríguez A (1975) Normas y técnicas de mediaciones antropométricas. Rev Hosp NinÄos 17:165–171
Lyon AJ, Preece MA, Grant DB (1985) Growth curve for girls with Turner syndrome. Arch Dis Child 60:932–935
McDowell MA, Fryar CD, Ogden CL (2009) Anthropometric reference data for children and adults: United States, 1988–1994. Vital Health Stat 11:1–68
Moritani T, Ahiara T, Oguma E et al (2006) Magnetic resonance venography of achondroplasia: correlation of venous narrowing at the jugular foramen with hydrocephalus. Clin Imaging 30:195–200
Orioli IM, Castilla EE, Scarano G, Mastroiacovo P (1995) Effect of paternal age in achondroplasia, thanatophoric dysplasia and osteogenesis imperfecta. Am J Med Genet 59:209–217
Shiang R, Thompson LM, Zhu YZ et al (1994) Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell 78:335–342
Spranger JW (2002) Achondroplasia. In: Spranger JW, Brill PW, Poznanski A (eds) Bone dysplasia: an atlas of genetic disorders of skeletal development, 2nd edn. Oxford University Press, New York, pp 83–89
Stokes DC, Phillips JA, Leonard CO et al (1983) Respiratory complications of achondroplasia. J Pediatr 102:534–541
Tachibana K, Suwa S, Nishiyama S, Matsuda I (1997) A study on the height of children with achondroplasia based on a nationwide survey. J Pediatr Pract 60:1363–1369 (In Japanese)
Tanner JM (1986) Use and abuse of growth standards. In: Falkner F, Tanner JM (eds) Human growth: a comprehensive treatise, vol 3, 2nd edn. Plenum, New York, pp 95–109
Trotter TL, Hall JG (2005) Health supervision for children with achondroplasia. American academy of pediatrics committee on genetics. Pediatrics 116:771–783, Erratum in Pediatrics 116:1615
Waller DK, Correa A, Vo TM et al (2008) The population-based prevalence of achondroplasia and thanatophoric dysplasia in selected regions of the US. Am J Med Genet A 146A:2385–2389
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To Tim Cole and Cristina Gatica.
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del Pino, M., Fano, V. & Lejarraga, H. Growth references for height, weight, and head circumference for Argentine children with achondroplasia. Eur J Pediatr 170, 453–459 (2011). https://doi.org/10.1007/s00431-010-1302-8
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DOI: https://doi.org/10.1007/s00431-010-1302-8