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Tick-borne encephalitis presenting as fever without localising signs—a case series

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Tick-borne encephalitis (TBE) presents without neurologic symptoms in 19% in children less than 16 years in Switzerland (2000–2008). In these cases, fever can be the only leading manifestation.

Case series

We report on four hospitalised children who had TBE and presented as fever without localising signs (FWLS) between 2000 and 2008 in an endemic area in Switzerland.


TBE infection has to be considered in the differential diagnosis of FWLS in endemic areas. Foremost, FWLS characterised by a biphasic fever course and accompanied by headache in patients in a reduced general condition. Affirming that in patients presenting as FWLS also cases of TBE are contained, this disease is underreported.

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Author information

Correspondence to Patrick Michael Meyer.

Additional information

Financial Support: None.

No authors have any financial/conflicting interests to disclose.

All authors were involved in the retrospective study and in writing the report.

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Meyer, P.M., Zimmermann, H. & Goetschel, P. Tick-borne encephalitis presenting as fever without localising signs—a case series. Eur J Pediatr 169, 767–769 (2010). https://doi.org/10.1007/s00431-009-1097-7

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  • Tick-borne encephalitis (TBE)
  • Fever without localising signs (FWLS)
  • Children
  • Switzerland