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Neonatal transient respiratory depression after maternal urapidil infusion for hypertension


Urapidil is a potent antihypertensive drug that has been in clinical use for more than 20 years. It has been proven to be an effective and well-tolerated antihypertensive drug during pregnancy, but clinical experiences with urapidil have been described in only a limited number of studies. There have also been only limited observations on the (side-)effects of urapidil on the neonate. We describe here a case of postnatal transient respiratory depression following maternal administration of urapidil. We suggest that the fetal and neonatal effects of more recently implemented antihypertensive drugs, such as urapidil, should be included in a prospective evaluation of antihypertensive treatment of women during pregnancy. Infants of mothers who received urapidil should be carefully watched in the immediate postnatal phase as urapidil may still exert some significant effects on the neonate.

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  1. 1.

    Curran A, Leiter J (2007) Baroreceptor-mediated inhibition after peripheral and central administration of a 5-HT1A receptor agonist in piglets. Exp Physiol 92:757–767

  2. 2.

    Gillis R, Hill K, Kirby J, Quest J, Hamosh P, Norman P, Kellar K (1989) Effect of activation of central nervous system serotonin 1A receptors on cardiorespiratory function. J Pharmacol Exper Toxicol 248:851–857

  3. 3.

    Goda Y (1993) Ventilatory mechanical analysis of respiratory depression induced by serotonin. Hokkaido Igaku Zasshi 68:29–41

  4. 4.

    Hanff L, Visser W, Vulto A, Steegers A (2006) Pharmacological treatment of severe pre-eclampsia. Eur Clinics Obstet Gynaecol 2:9–17

  5. 5.

    König J, Meier-Dörzenbach E, Menge H, Müller H, Padberg G, Petersen-Knoche C, Schäfer H (1977) Toxicology study in the antihypertensive agent urapidil. Arzneimittelforschung 27:1919–1932

  6. 6.

    Schulz M, Wacker J, Bastert G (2001) Effect of urapidil in antihypertensive therapy of preclampsia on newborns. Zentralbl Gynakol 123:529–533

  7. 7.

    Wacker J, Müller J, Unkels R, Bastert G (1994) Antihypertensive therapie bei schwangerschaftsinduzierter hypertonie (SIH) mit urapidil. Zentralalbl Gynäkol 116:271–273

  8. 8.

    Wacker J, Wagner B, Briese V, Schauf B, Heilmann L, Bartz C, Hopp H (2006) Antihypertensive therapy in patients with pre-eclampsia: a prospective randomised multicentre study comparing dihydralazine with urapidil. Eur J Obstet Gynecol Reprod Biol 127:160–165

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Correspondence to Sophie Vanhaesebrouck.

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The authors declare that there is no external funding source.

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Vanhaesebrouck, S., Hanssens, M. & Allegaert, K. Neonatal transient respiratory depression after maternal urapidil infusion for hypertension. Eur J Pediatr 168, 221–223 (2009).

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  • Hypertension
  • Neonate
  • Respiratory depression
  • Urapidil