Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Prognosis of antenatally diagnosed oligohydramnios of renal origin

  • 373 Accesses

  • 20 Citations

Abstract

Although clinical outcome data on fetuses with oligohydramnios of renal origin are scarce, prognosis is regarded as poor due to a high risk of renal dysfunction and pulmonary hypoplasia. This review aims to summarize the current knowledge and clinical experience with patients presenting antenatally with renal oligohydramnios. By reviewing the underlying mechanisms, complications, and outcome data, we hope to further improve antenatal counseling and postnatal care. We conclude that prognosis of ROH has changed in recent years. While early data before the introduction of sophisticated neonatal intensive care and renal replacement therapy indicated a poor prognosis, nowadays, a much more optimistic prognosis of children after renal oligohydramnios can be expected from the recent publications in the literature.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Abe Y, Mizuno K, Horie H, Matsumoto M, Yamaoka A, Mizutani K, Takeuchi T, Iikura Y (2002) Potter sequence complicated by congenital cystic lesion of the bladder. Am J Perinatol 19(5):267–272

  2. 2.

    Biard JM, Johnson MP, Carr MC, Wilson RD, Hedrick HL, Pavlock C, Adzick NS (2005) Long-term outcomes in children treated by prenatal vesicoamniotic shunting for lower urinary tract obstruction. Obstet Gynecol 106(3):503–508

  3. 3.

    Bronshtein M, Blumenfeld Z (1991) First- and early second-trimester oligohydramnios—a predictor of poor fetal outcome except in iatrogenic oligohydramnios post chorionic villus biopsy. Ultrasound Obstet Gynecol 1(4):245–249

  4. 4.

    Bunchman TE (2000) Infant dialysis: the future is now. J Pediatr 136(1):1–2

  5. 5.

    Campbell S, Pearce JM (1983) Ultrasound visualization of congenital malformations. Br Med Bull 39(4):322–331

  6. 6.

    Chauhan SP, Doherty DD, Magann EF, Cahanding F, Moreno F, Klausen JH (2004) Amniotic fluid index vs single deepest pocket technique during modified biophysical profile: a randomized clinical trial. Am J Obstet Gynecol 191(2):661–667; Discussion 667–668

  7. 7.

    Chevalier RL (2006) Pathogenesis of renal injury in obstructive uropathy. Curr Opin Pediatr 18(2):153–160

  8. 8.

    De Carolis MP, Romagnoli C, De Santis M, Piersigilli F, Vento G, Caruso A (2004) Is there significant improvement in neonatal outcome after treating pPROM mothers with amnio-infusion? Biol Neonate 86(4):222–229

  9. 9.

    Eckoldt F, Heling KS, Woderich R, Wolke S (2004) Posterior urethral valves: prenatal diagnostic signs and outcome. Urol Int 73(4):296–301

  10. 10.

    El-Ghoneimi A, Desgrippes A, Luton D, Macher MA, Guibourdenche J, Garel C, Muller F, Vuillard E, Lottmann H, Nessmann C, Oury JF, Aigrain Y (1999) Outcome of posterior urethral valves: to what extent is it improved by prenatal diagnosis? J Urol 162(3 Pt 1):849–853

  11. 11.

    Fischler BR, Berg UB (1994) Potter sequence and consanguinity—a case report. Pediatr Nephrol 8(1):81–82

  12. 12.

    Freedman AL, Johnson MP, Gonzalez R (2000) Fetal therapy for obstructive uropathy: past, present, future? Pediatr Nephrol 14(2):167–176

  13. 13.

    Freedman AL, Johnson MP, Smith CA, Gonzalez R, Evans MI (1999) Long-term outcome in children after antenatal intervention for obstructive uropathies. Lancet 354(9176):374–377

  14. 14.

    Gloor JM, Ogburn PL Jr, Breckle RJ, Morgenstern BZ, Milliner DS (1995) Urinary tract anomalies detected by prenatal ultrasound examination at Mayo Clinic Rochester. Mayo Clin Proc 70(6):526–531

  15. 15.

    Gramellini D, Fieni S, Kaihura C, Piantelli G, Verrotti C (2003) Antepartum amnioinfusion: a review. J Matern Fetal Neonatal Med 14(5):291–296

  16. 16.

    Hadlock FP, Deter RL, Carpenter R, Gonzalez ET, Park SK (1981) Sonography of fetal urinary tract anomalies. AJR Am J Roentgenol 137(2):261–267

  17. 17.

    Harrison MR, Golbus MS, Filly RA, Nakayama DK, Callen PW, de Lorimier AA, Hricak H (1982) Management of the fetus with congenital hydronephrosis. J Pediatr Surg 17(6):728–742

  18. 18.

    Kari JA, Gonzalez C, Ledermann SE, Shaw V, Rees L (2000) Outcome and growth of infants with severe chronic renal failure. Kidney Int 57(4):1681–1687

  19. 19.

    Kemper MJ, Muller-Wiefel DE (2001) Renal function in congenital anomalies of the kidney and urinary tract. Curr Opin Urol 11(6):571–575

  20. 20.

    Kemper MJ, Neuhaus TJ, Timmermann K, Hueneke B, Laube G, Harps E, Mueller-Wiefel DE (2001) Antenatal oligohydramnios of renal origin: postnatal therapeutic and prognostic challenges. Clin Nephrol 56(6):S9–S12

  21. 21.

    Klaassen I, Neuhaus TJ, Mueller-Wiefel DE, Kemper MJ (2006) Antenatal oligohydramnios of renal origin: long-term outcome. Nephrol Dial Transplant (electronic publication 25 October 2006)

  22. 22.

    Kuwayama F, Miyazaki Y, Ichikawa I (2002) Embryogenesis of the congenital anomalies of the kidney and the urinary tract. Nephrol Dial Transplant 17(Suppl 9):45–47

  23. 23.

    Lam BC, Wong SN, Yeung CY, Tang MH, Ghosh A (1993) Outcome and management of babies with prenatal ultrasonographic renal abnormalities. Am J Perinatol 10(4):263–268

  24. 24.

    Ledermann SE, Scanes ME, Fernando ON, Duffy PG, Madden SJ, Trompeter RS (2000) Long-term outcome of peritoneal dialysis in infants. J Pediatr 136(1):24–29

  25. 25.

    Magann EF, Isler CM, Chauhan SP, Martin JN Jr (2000) Amniotic fluid volume estimation and the biophysical profile: a confusion of criteria. Obstet Gynecol 96(4):640–642

  26. 26.

    Miguelez J, Bunduki V, Yoshizaki CT, Sadek Ldos S, Koch V, Peralta CF, Zugaib M (2006) Fetal obstructive uropathy: is urine sampling useful for prenatal counselling? Prenat Diagn 26(1):81–84

  27. 27.

    Muller F, Dreux S, Audibert F, Chabaud JJ, Rousseau T, D’Herve D, Dumez Y, Ngo S, Gubler MC, Dommergues M (2004) Fetal serum ss2-microglobulin and cystatin C in the prediction of post-natal renal function in bilateral hypoplasia and hyperechogenic enlarged kidneys. Prenat Diagn 24(5):327–332

  28. 28.

    Nakayama DK, Harrison MR, de Lorimier AA (1986) Prognosis of posterior urethral valves presenting at birth. J Pediatr Surg 21(1):43–45

  29. 29.

    Ott WJ (2005) Reevaluation of the relationship between amniotic fluid volume and perinatal outcome. Am J Obstet Gynecol 192(6):1803–1809; Discussion 1809

  30. 30.

    Podevin G, Mandelbrot L, Vuillard E, Oury JF, Aigrain Y (1996) Outcome of urological abnormalities prenatally diagnosed by ultrasound. Fetal Diagn Ther 11(3):181–190

  31. 31.

    Rani R, Cameron A, Munro F (1997) Prenatal diagnosis and management of urethral obstruction. J Obstet Gynaecol Res 23(1):59–62

  32. 32.

    Robyr R, Benachi A, Daikha-Dahmane F, Martinovich J, Dumez Y, Ville Y (2005) Correlation between ultrasound and anatomical findings in fetuses with lower urinary tract obstruction in the first half of pregnancy. Ultrasound Obstet Gynecol 25(5):478–482

  33. 33.

    Ross MG, Brace RA, National Institute of Child Health and Development Workshop Participants (2001) National Institute of Child Health and Development Conference summary: amniotic fluid biology—basic and clinical aspects. J Matern Fetal Med 10(1):2–19

  34. 34.

    Shroff R, Rees L, Trompeter R, Hutchinson C, Ledermann S (2006) Long-term outcome of chronic dialysis in children. Pediatr Nephrol 21(2):257–264

  35. 35.

    Smith NP, Losty PD, Connell MG, Mayer U, Jesudason EC (2006) Abnormal lung development precedes oligohydramnios in a transgenic murine model of renal dysgenesis. J Urol 175(2):783–786

  36. 36.

    Stoll C, Alembik Y, Roth MP, Dott B (1998) Study of 224 cases of oligohydramnios and congenital malformations in a series of 225,669 consecutive births. Community Genet 1(2):71–77

  37. 37.

    Uga N, Ishii T, Kawase Y, Arai H, Tada H (2004) Nitric oxide inhalation therapy in very low-birthweight infants with hypoplastic lung due to oligohydramnios. Pediatr Int 46(1):10–14

  38. 38.

    Van Dyck M, Bilem N, Proesmans W (1999) Conservative treatment for chronic renal failure from birth: a 3-year follow-up study. Pediatr Nephrol 13(9):865–869

  39. 39.

    Zaccara A, Giorlandino C, Mobili L, Brizzi C, Bilancioni E, Capolupo I, Capitanucci ML, De Gennaro M (2005) Amniotic fluid index and fetal bladder outlet obstruction. Do we really need more? J Urol 174(4 Pt 2):1657–1660

  40. 40.

    Zaretsky M, Ramus R, McIntire D, Magee K, Twickler DM (2005) MRI calculation of lung volumes to predict outcome in fetuses with genitourinary abnormalities. AJR Am J Roentgenol 185(5):1328–1334

Download references

Author information

Correspondence to Markus J. Kemper.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kemper, M.J., Mueller-Wiefel, D.E. Prognosis of antenatally diagnosed oligohydramnios of renal origin. Eur J Pediatr 166, 393–398 (2007). https://doi.org/10.1007/s00431-006-0368-9

Download citation

Keywords

  • Antenatal
  • Ultrasound
  • Renal oligohydramnios (ROH)
  • Outcome
  • Chronic renal failure
  • Chronic kidney disease
  • Congenital anomalies of kidney and urinary tract (CAKUT)
  • Pulmonary hypoplasia