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Serum levels of IgG to the peptide of HCV1b core at positions 35–44 correlated with persistent infection, while levels of IgG to the peptide of NS5A at positions 2132–2140 correlated with better prognosis in HCV-infected patients

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We previously reported that two IgG Abs to the hepatitis C virus (HCV), anti-core 35–44 (C35) and anti-NS5A 2132–2140 (NS5A2132), existed in the sera of the majority of patients with HCV infection. This study investigated if measuring the two Abs would facilitate the prediction of a patient’s prognosis. The serum levels of anti-C35 were found to correlate with persistent infection, while those of anti-NS5A2132 correlated with a better prognosis in HCV-infected patients. These results suggest that sequential measurement of the two Abs together may provide new information for the prediction of prognosis.

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This study was supported in part by Grants-in-Aid from the Ministry of Education, Science, Sports, and Culture of Japan (no. 12213134 to K.I. and the 21st Century COE Program for Medical Science to K.I. and A.Y.) and from the Ministry of Health, Labor and Welfare, Japan (no. H14-trans-002 11–16 to K.I.).

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Correspondence to Akira Yamada.

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Takao, Y., Yamada, A., Yutani, S. et al. Serum levels of IgG to the peptide of HCV1b core at positions 35–44 correlated with persistent infection, while levels of IgG to the peptide of NS5A at positions 2132–2140 correlated with better prognosis in HCV-infected patients. Med Microbiol Immunol 196, 157–164 (2007). https://doi.org/10.1007/s00430-007-0038-1

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  • HCV
  • Peptide
  • Antibody
  • Prognosis
  • CTL-epitope