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Brain Structure and Function

, Volume 224, Issue 5, pp 1925–1932 | Cite as

Dissociable effects of dopamine D1 and D2 receptors on compulsive ingestion and pivoting movements elicited by disinhibiting the ventral pallidum

  • Rhett A. ReichardEmail author
  • Kenneth P. Parsley
  • Suriya Subramanian
  • Daniel S. ZahmEmail author
Original Article
  • 120 Downloads

Abstract

Previous studies have shown that infusion of a GABAA receptor antagonist, such as bicuculline (bic), into the ventral (pallidum VP) of rats elicits vigorous ingestion in sated subjects and abnormal pivoting movements. Here, we assessed if the ingestive effects generalize to the lateral preoptic area (LPO) and tested both effects for modulation by dopamine receptor signaling. Groups of rats received injections of the dopamine D2 receptor antagonist, haloperidol (hal), the D1 antagonist, SCH-23390 (SCH), or vehicle (veh) followed by infusions of bic or veh into the VP or LPO. Ingestion effects were not observed following LPO bic infusions. Compulsive ingestion associated with VP activation was attenuated by hal, but not SCH. VP bic-elicited pivoting was attenuated by neither hal, nor SCH.

Keywords

Basal forebrain Locomotion Feeding Bicuculline 

Notes

Funding

The work was supported by USPHS NIH Grant NS-23805 to DSZ. RAR received support from USPHS NIH Grant T32 GM008306.

Compliance with ethical standards

Conflict of interest

The authors report no conflicts of interest

Research involving human participants and/or animals

There were no human subjects. Male Sprague-Dawley rats (Harlan, Indianapolis, IN) weighing 250–375 g were used in accordance with policy mandated in the Public Health Service Policy on Humane Care and Use of Laboratory Animals (http://grants.nih.gov/grants/olaw/references/phspol.htm) provided by the U.S. Department of Health and Human Services with oversight by the Saint Louis University Animal Care Committee. Veterinary care was provided by the Saint Louis University Department of Comparative Medicine.

Ethical approval

All authors read and approved the final submitted manuscript.

Informed consent

There were no human subjects.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Pharmacology and PhysiologySaint Louis University School of MedicineSaint LouisUSA
  2. 2.Department of NeuroscienceMedical University of South CarolinaCharlestonUSA

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