A population-based atlas of the human pyramidal tract in 410 healthy participants
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With the advances in diffusion MRI and tractography, numerous atlases of the human pyramidal tract (PyT) have been proposed, but the inherent limitation of tractography to resolve crossing bundles within the centrum semiovale has so far prevented the complete description of the most lateral PyT projections. Here, we combined a precise manual positioning of individual subcortical regions of interest along the descending pathway of the PyT with a new bundle-specific tractography algorithm. This later is based on anatomical priors to improve streamlines tracking in crossing areas. We then extracted both left and right PyT in a large cohort of 410 healthy participants and built a population-based atlas of the whole-fanning PyT with a complete description of its most corticolateral projections. Clinical applications are envisaged, the whole-fanning PyT atlas being likely a better marker of corticospinal integrity metrics than those currently used within the frame of prediction of poststroke motor recovery. The present population-based PyT, freely available, provides an interesting tool for clinical applications to locate specific PyT damage and its impact to the short- and long-term motor recovery after stroke.
KeywordsWhite-matter anatomy Pyramidal tract Corticospinal tract Corticobulbar tract Healthy human Diffusion imaging Tractography
We are grateful to Dr. Thomas Tourdias for the helpful comments and discussion.
No specific funding to mention.
Compliance with ethical standards
Conflict of interest
No conflicts of interest.
The study was approved by the local ethics committee (CCPRB Basse-Normandie).
All participants gave written consent prior to participation in the study.
Research involving human participants
The current research involved human participants.
- Armand J (1982) The origin, course and terminations of corticospinal fibers in various mammals. In: Kuypers HGJM, Martin GF (eds) Progress in brain research, Elsevier, New York, pp 329–360Google Scholar
- Côté M-A, Garyfallidis E, Larochelle H, Descoteaux M (2015) Cleaning up the mess: tractography outlier removal using hierarchical QuickBundles clustering. In: 23rd ISMRM Annual Meeting. Toronto, CanadaGoogle Scholar
- De Benedictis A, Petit L, Descoteaux M, Marras CE, Barbareschi M, Corsini F, Dallabona M, Chioffi F, Sarubbo S (2016) New insights in the homotopic and heterotopic connectivity of the frontal part of the human corpus callosum revealed by microdissection and diffusion tractography. Hum Brain Mapp 37:4718–4735CrossRefPubMedGoogle Scholar
- Dejerine J, Dejerine-Klumpke A (1901) Anatomie des centres nerveux. Tome 2. Rueff et Cie, ParisGoogle Scholar
- Hau J, Sarubbo S, Houde JC, Corsini F, Girard G, Deledalle C, Crivello F, Zago L, Mellet E, Jobard G, Joliot M, Mazoyer B, Tzourio-Mazoyer N, Descoteaux M, Petit L (2017) Revisiting the human uncinate fasciculus, its subcomponents and asymmetries with stem-based tractography and microdissection validation. Brain Struct Funct 222:1645–1662CrossRefPubMedGoogle Scholar
- Mazoyer B, Mellet E, Perchey G, Zago L, Crivello F, Jobard G, Delcroix N, Vigneau M, Leroux G, Petit L, Joliot M, Tzourio-Mazoyer N (2016) BIL&GIN: a neuroimaging, cognitive, behavioral, and genetic database for the study of human brain lateralization. Neuroimage 124 Part B:1225–1231CrossRefGoogle Scholar
- Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TEJ, Johansen-Berg H, Bannister PR, De Luca M, Drobnjak I, Flitney DE, Niazy RK, Saunders J, Vickers J, Zhang Y, De Stefano N, Brady JM, Matthews PM (2004) Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage 23 Supplement 1:S208–S219CrossRefPubMedGoogle Scholar
- Thiebaut de Schotten M, Ffytche D, Bizzi A, Dell’acqua F, Allin M, Walshe M, Murray R, Williams S, Murphy DGM, Catani M (2011) Atlasing location, asymmetry and inter-subject variability of white matter tracts in the human brain with MR diffusion tractography. NeuroImage 54:49–59CrossRefPubMedGoogle Scholar
- Yendiki A, Panneck P, Srinivasan P, Stevens A, Zollei L, Augustinack J, Wang R, Salat D, Ehrlich S, Behrens T, Jbabdi S, Gollub R, Fischl B (2011) Automated probabilistic reconstruction of white-matter pathways in health and disease using an atlas of the underlying anatomy. Front Neuroinform 5:23CrossRefPubMedPubMedCentralGoogle Scholar
- Zhang Y, Zhang J, Oishi K, Faria AV, Jiang H, Li X, Akhter K, Rosa-Neto P, Pike GB, Evans A, Toga AW, Woods R, Mazziotta JC, Miller MI, van Zijl PCM, Mori S (2010) Atlas-guided tract reconstruction for automated and comprehensive examination of the white matter anatomy. NeuroImage 52:1289–1301CrossRefPubMedPubMedCentralGoogle Scholar