Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Anosognosia for obvious visual field defects in stroke patients

Abstract

Patients with anosognosia for visual field defect (AVFD) fail to recognize consciously their visual field defect. There is still unclarity whether specific neural correlates are associated with AVFD. We studied AVFD in 54 patients with acute stroke and a visual field defect. Nineteen percent of this unselected sample showed AVFD. By using modern voxelwise lesion-behaviour mapping techniques we found an association between AVFD and parts of the lingual gyrus, the cuneus as well as the posterior cingulate and corpus callosum. Damage to these regions appears to induce unawareness of visual field defects and thus may play a significant role for conscious visual perception.

This is a preview of subscription content, log in to check access.

Fig. 1
Fig. 2

References

  1. Anton G (1899) Über die Selbstwahrnehmung der Herderkrankungen des Gehirns durch den Kranken bei Rindenblindheit und Rindentaubheit. Arch Psychiatr Nervenkrankh 32:86–127

  2. Baier B, Karnath H-O (2005) Incidence and diagnosis of anosognosia for hemiparesis revisited. J Neurol Neurosurg Psychiatry 76:358–361

  3. Bisiach E, Vallar G, Perani D et al (1986) Unawareness of disease following lesions of the right hemisphere: anosognosia for hemiplegia and anosognosia for hemianopsia. Neuropsychologia 24:471–482

  4. Brett M, Leff AP, Rorden C, Ashburner J (2001) Spatial normalisation of brain images with focal lesions using cost function masking. Neuroimage 14:486–500

  5. Celesia GG, Brigell MG, Vaphiades MS (1997) Hemianopic anosognosia. Neurology 49:88–97

  6. Cohen SY, Legargasson JF (2005) Adaptation to central scotoma. Part II Perceptual filling-in phenomenon. J Fr Ophtalmol 28:1131–1136

  7. Eickhoff SB, Stephan KE, Mohlberg H et al (2005) A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data. Neuroimage 25:1325–1335

  8. Ffytche DH, Blom JD, Catani M (2010) Disorders of visual perception. J Neurol Neurosurg Psychiatry 81:1280–1287

  9. Gauthier L, Dehaut F, Joanette Y (1989) The bells test: a quantitative and qualitative test for visual neglect. Int J Clin Neuropsychol 11:49–54

  10. Hayashi R, Shimizu S, Watanabe R et al (2002) Palinopsia and perilesional hyperperfusion following subcortical hemorrhage. Acta Neurol Scand 105:228–231

  11. Koehler PJ, Endtz LJ, Te Velde J, Hekster RE (1986) Aware or non-aware. On the significance of awareness for the localization of the lesion responsible for homonymous hemianopsia. J Neurol Sci 75:255–262

  12. Milandre L, Brosset C, Botti G, Khalil R (1994) A study of 82 cerebral infarctions in the area of posterior cerebral arteries. Rev Neurol 150:133–141

  13. Pins D, Ffytche D (2003) The neural correlates of conscious vision. Cereb Cortex 13:461–474

  14. Ramachandran VS, Gregory RL (1991) Perceptual filling in of artificially induced scotomas in human vision. Nature 1991(350):699–702

  15. Rees G, Kreiman G, Koch C (2002) Neural correlates of consciousness in humans. Nat Rev Neurosci 3:261–270

  16. Rorden C, Karnath H-O (2004) Using human brain lesions to infer function: a relic from a past era in the fMRI age? Nat Rev Neurosci 5:813–819

  17. Rorden C, Karnath H-O (2010) A simple measure of neglect severity. Neuropsychologia 48:2758–2763

  18. Rorden C, Karnath H-O, Bonilha L (2007) Improving lesion-symptom mapping. J Cogn Neurosci 19:1081–1088

  19. Spatt J, Mamoli B (2000) Ictal visual hallucinations and post-ictal hemianopia with anosognosia. Seizure 9:502–504

  20. Stoerig P, Barth E (2001) Low-level phenomenal vision despite unilateral destruction of primary visual cortex. Conscious Cogn 10:574–587

  21. Suchan J, Rorden C, Karnath H-O (2012) Neglect severity after left and right brain damage. Neuropsychologia 50:1136–1141

  22. Vuilleumier P, Sagiv N, Hazeltine E et al (2001) Neural fate of seen and unseen faces in visuospatial neglect: a combined event-related functional MRI and event-related potential study. Proc Natl Acad Sci USA 98:3495–3500

Download references

Acknowledgments

This work was supported by the Deutsche Forschungsgemeinschaft (KA 1258/10-1, HA 5839/3-1, and BA 4097/1-1) and the Bundesministerium für Bildung und Forschung (BMBF) (IFB) to MD.

Conflict of interest

The authors report no conflicts of interest.

Author information

Correspondence to Bernhard Baier.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Baier, B., Geber, C., Müller-Forell, W. et al. Anosognosia for obvious visual field defects in stroke patients. Brain Struct Funct 220, 1855–1860 (2015). https://doi.org/10.1007/s00429-014-0753-5

Download citation

Keywords

  • Anosognosia
  • Visual field defect
  • Consciousness
  • Visual perception
  • Stroke
  • Human