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Lymphoproliferations at extranodal sites: a morphologically, genetically, and clinically diverse group of neoplasms with overlapping features

  • John R. GoodladEmail author
  • German Ott
Commentary
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Commentary

The World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues represents a list of diseases regarded to be distinct entities, grouped together on the basis of shared morphology, immunophenotype, and genetic features. Clinical characteristics also make an important contribution when it comes to separating specific disease subgroups. For certain lymphomas, origin of disease, particularly at extranodal locations, is increasingly recognized as an important determinant of behavior and outcome. Extranodal presentation of lymphoma is common, with many cases encountered in the skin, stomach, small intestine, and brain, but virtually any organ can be involved [16]. They often represent a diagnostic challenge, encompassing a broad range of histological subtypes harboring a variety of molecular abnormalities and displaying a spectrum of clinical behaviors. Compared with nodal lymphomas displaying similar pathological features, they frequently...

Notes

Acknowledgments

The authors thank all the workshop participants for their case submissions and contributions during the meeting. Without this input, the workshop could not have taken place.

Authors’ contributions

John Goodlad and German Ott conceived, designed, and jointly wrote the commentary.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Both authors declare strict adherence to compliance with ethical standards.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Department of PathologyQueen Elizabeth University HospitalGlasgowScotland
  2. 2.Department of Clinical PathologyRobert-Bosch-KrankenhausStuttgartGermany

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