Fetal and perinatal growth charts and tables are essential for proper interpretation of autopsy anthropometric parameters. These parameters depend on factors that may vary between populations; thus, it is recommended that standards be developed from local target populations to ensure that they are truly representative. In this study, we established standards for a complete set of autopsy fetal parameters, including biometrical measurements, organ weights and long bone lengths, based on autopsy data collected retrospectively from a sample of Portuguese fetuses and neonates. Using a robust statistical regression methodology, to fit mean and standard deviation models, we constructed growth curves for gestational ages between 12 and 42 weeks, which aim to be useful for autopsy examination, particularly in the Portuguese population.
Fetal biometry Organ weights Portuguese Autopsy Reference values
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Liliana Costa and Nuno Botelho collected the data and pictures; Isabel Vilar and Marta Rodrigues constructed the database; Carla Bartosch designed the project, analyzed the data, and wrote the manuscript draft; Otilia Brandão supervised all the work and critically revised the manuscript text.
Compliance with ethical standards
This study was conducted at the Centro Hospitalar S. João in Porto, Portugal, after being approved by the hospital’s ethics committee (CES 334.15).
Conflict of interest
The authors declare that they have no conflict of interest.
Online Resource 4- Supplementary table - Mathematical equations of fitted mean models and corresponding R2 for fetal anthropometric autopsy parameters. (DOCX 16 kb)
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