Virchows Archiv

, Volume 475, Issue 4, pp 519–525 | Cite as

SOX11 expression in a case of papillary thyroid carcinoma with fibromatosis/fasciitis-like stroma containing BRAF c.1799_1801delTGA and CTNNB1 c.133T>C mutations

  • Soon Boon Justin Wong
  • Min En Nga
  • Michal Michal
  • Tomas Vanecek
  • Ju Ee Seet
  • Fredrik PeterssonEmail author
Brief Report


We describe a case of papillary thyroid carcinoma with fibromatosis/fasciitis-like stroma (PTC-FLS) that contained the rare BRAF c.1799_1801delTGA (p.V600_K601delinsE) mutation, which has not previously been reported in this tumour, as well as the CTNNB1 c.133T>C (p.S45P) mutation. We also report the novel observation that spindle cells of the mesenchymal component exhibit diffuse nuclear but not cytoplasmic expression of SOX11, whereas the malignant epithelial cells did not. This suggests that immunoreactivity for SOX11 can be an alternative diagnostic tool for evaluating cases of PTC-FLS where the nuclear expression of β-catenin is ambiguous.


Papillary thyroid carcinoma Fibromatosis/fasciitis-like stroma SOX11 β-Catenin BRAF Mutation 


Authors’ contributions

SBJW: tissue sampling, histological analysis, interpretation of data, literature review, drafting and review of manuscript. MEN: histological analysis, interpretation of data and review of manuscript. TV and MM: analysis of molecular features. JES: cytological analysis and review of manuscript. FP: histological analysis, interpretation of data, literature review, review of manuscript, study supervision, study design, decision to submit and publish the manuscript. All authors gave the final approval for publication.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standard

This is a brief report on a novel and unique case of diagnostic interest; it is not a research project; there is no human or animal participant(s). It is our institution’s policy not to require consent for studies up to two subjects.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Soon Boon Justin Wong
    • 1
    • 2
  • Min En Nga
    • 1
  • Michal Michal
    • 3
  • Tomas Vanecek
    • 4
  • Ju Ee Seet
    • 5
  • Fredrik Petersson
    • 1
    • 5
    Email author
  1. 1.Department of PathologyNational University HospitalSingaporeSingapore
  2. 2.Department of Microbiology and ImmunologyNational University of SingaporeSingaporeSingapore
  3. 3.Department of Pathology, Faculty of Medicine in PlzenCharles UniversityPlzenCzech Republic
  4. 4.Molecular and Genetic LaboratoryBiopticka Laboratory Ltd.PlzenCzech Republic
  5. 5.Department of PathologyNational University Health SystemSingaporeSingapore

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