ALK-negative anaplastic large cell lymphoma arising in the thrombus of an aortic prosthesis preceeded by clonally related lymphomatoid papulosis

  • Thomas Menter
  • Veronika Ballova
  • Clemens Caspar
  • Thomas Wolff
  • Benjamin Kasenda
  • Gad Singer
  • Darius Juskevicius
  • Alexandar Tzankov
  • Stefan DirnhoferEmail author
Brief Communication


We report on a 73-year-old male patient with recurrent thrombosis of his infrarenal aortic prosthesis. Histologically, the thrombus contained cells of an ALK-negative anaplastic large cell T cell lymphoma (ALCL). Imaging studies were negative for other lymphoma manifestations; however, 3 months before, the patient had developed skin lesions consistent with lymphomatoid papulosis type A (LypA) which were clonally related to the ALCL. Due to recurrent thrombosis of larger peripheral arteries with the presence of ALCL cells in the thrombi, the patient is now referred to systemic chemotherapy. We present the first case of ALCL manifesting in the thrombus of an aortic prosthesis. This case shows similarities to the well-established entity of breast implant-associated ALCL and anecdotal reports of ALCL occurring at the site of foreign material implants. These cells show a peculiar propensity to aggregate in vessels and thrombi, known primarily from subtypes of diffuse large B cell lymphomas associated with chronic inflammation.


Anaplastic large cell lymphoma Lymphomatoid papulosis PTFE Aortic prosthesis Breast implant-associated ALCL 



We thank Dr. Charlotte K Y Ng for critically reading the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Thomas Menter
    • 1
  • Veronika Ballova
    • 2
  • Clemens Caspar
    • 2
  • Thomas Wolff
    • 3
  • Benjamin Kasenda
    • 4
  • Gad Singer
    • 5
  • Darius Juskevicius
    • 1
  • Alexandar Tzankov
    • 1
  • Stefan Dirnhofer
    • 1
    Email author
  1. 1.Institute of Pathology and Medical GeneticsUniversity Hospital BaselBaselSwitzerland
  2. 2.Department of Medical OncologyCantonal Hospital BadenBadenSwitzerland
  3. 3.Department of Vascular SurgeryUniversity Hospital BaselBaselSwitzerland
  4. 4.Department of Medical OncologyUniversity Hospital BaselBaselSwitzerland
  5. 5.Institute of PathologyCantonal Hospital BadenBadenSwitzerland

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